Protein Alignment Rab8 and RAB35

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_006852.1
• Gene: RAB35 / 11021
• HGNCID: 9774
• Length: 201
• Species: Homo sapiens
• Alignment Length: 185
• Identity: 91/185 - (49%)
• Similarity: 134/185 - (72%)
• Gaps: 8/185 - (4%)

  Fly     1 MAKTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKKIKLQIWDTA 65
            ||:.||:|||||:||||||||:.:|.||:::.|:.::|:|||:||||||:|::.:|:||||||||
Human     1 MARDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDTA 65

  Fly    66 GQERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENASADVEKMLLGNKCELTDKRQ 130
            |||||||||:.||||..|:::|||:|..:||.|:|.|:..|.:|.. ||.::|:|||.:..:::.
Human    66 GQERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEINQNCD-DVCRILVGNKNDDPERKV 129

  Fly   131 VSKERGEQLAIEYGIKFMETSAKASINVEEAF-------LTLASDIKAKTEKRME 178
            |..|...:.|.:.||:..|||||.::||||.|       |....|..||.:::.:
Human   130 VETEDAYKFAGQMGIQLFETSAKENVNVEEMFNCITELVLRAKKDNLAKQQQQQQ 184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	86/172 (50%)
RAB35	NP_006852.1	Rab35	3..201	CDD:133310	89/183 (49%)
		Switch 1. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	30..42		3/11 (27%)
		Switch 2. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	64..80		13/15 (87%)