Protein Alignment Rab8 and RAB32

DIOPT Version :10

• Sequence 1: NP_524172.1
• Gene: Rab8 / 40168
• FlyBaseID: FBgn0262518
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_006825.1
• Gene: RAB32 / 10981
• HGNCID: 9772
• Length: 225
• Species: Homo sapiens
• Alignment Length: 173
• Identity: 63/173 - (36%)
• Similarity: 105/173 - (60%)
• Gaps: 6/173 - (3%)

  Fly     3 KTYDYLFKLLLIGDSGVGKTCILFRFSEDAFNTTFISTIGIDFKIRTIELDNKK-IKLQIWDTAG 66
            :|.::|||:|:||:.|||||.|:.|:....|:..:.:|||:||.::.:..|::. ::||:||.||
Human    20 ETREHLFKVLVIGELGVGKTSIIKRYVHQLFSQHYRATIGVDFALKVLNWDSRTLVRLQLWDIAG 84

  Fly    67 QERFRTITTAYYRGAMGIMLVYDITQEKSFENIKNWIRNIEENA----SADVEKMLLGNKCELTD 127
            ||||..:|..||:.|:|..:|:||::..:||.:..|..:::...    .:.:..:||.|||:...
Human    85 QERFGNMTRVYYKEAVGAFVVFDISRSSTFEAVLKWKSDLDSKVHLPNGSPIPAVLLANKCDQNK 149

  Fly   128 KRQVSKERGEQLAIEYGIK-FMETSAKASINVEEAFLTLASDI 169
            ....|..:.:|...|:|.. :.|||||.:||:|||...|...|
Human   150 DSSQSPSQVDQFCKEHGFAGWFETSAKDNINIEEAARFLVEKI 192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab8	NP_524172.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	62/170 (36%)
RAB32	NP_006825.1	Rab32_Rab38	26..224	CDD:206692	61/167 (37%)
		Switch 1. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	48..62		4/13 (31%)
		Switch 2. /evidence=ECO:0000269|PubMed:24856514, ECO:0007744|PDB:4CYM, ECO:0007744|PDB:4CZ2	84..97		7/12 (58%)
		PKA-RII subunit binding domain	178..197		7/15 (47%)