Protein Alignment Papss and PAPSS2

DIOPT Version :10

• Sequence 1: NP_730460.1
• Gene: Papss / 40167
• FlyBaseID: FBgn0020389
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_001015880.1
• Gene: PAPSS2 / 9060
• HGNCID: 8604
• Length: 619
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 392/629 - (62%)
• Similarity: 492/629 - (78%)
• Gaps: 14/629 - (2%)

  Fly    33 LPSVEKPEDACLQVATNVTEQKHHVTRETRGKNLGLCRGFRGCTVWLTGLSGAGKTSIAFELEAY 97
            :..::|.:....|.:|||..|.|||:|..||:.:|...||||||||||||||||||:|:|.||.|
Human     1 MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEY 65

  Fly    98 LVSRGIPAYGLDGDNIRTGLNKNLGFTPADREENIRRVGEVAKLFADSGVVAICSFVSPFADDRE 162
            |||..||.|.|||||:|.|||:||||:|.||||||||:.||||||||:|:|.|.||:||||.|||
Human    66 LVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRE 130

  Fly   163 MARKIHKDAGLKFYEIFVDTPLDVCETRDVKGLYKKAREGVIKGFTGITQEYERPQMPELVVNTH 227
            .|||||:.|||.|:|||||.||::||:||||||||:||.|.|||||||..:||:|:.||.|:.|:
Human   131 NARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTN 195

  Fly   228 GYTVRESTQKLVTLLEQEGIIPRS-LRDVDLLPELYPSESIATEALRHEAESLQAIEISTVELQW 291
            ..||.:...::|.||:::.|:|.: ::|:.   ||:..|: ..:.:|.|||:|.::.|:.::|||
Human   196 LSTVSDCVHQVVELLQEQNIVPYTIIKDIH---ELFVPEN-KLDHVRAEAETLPSLSITKLDLQW 256

  Fly   292 VQVLAEGWAYPLRGFMREDEYLQTLHFNTLQSGM---DGSYRENHSVPIVLSATQADKDRLDGCS 353
            ||||:||||.||:|||||.||||.:||:||..||   ||..  |.|:||||..:..||.||:|||
Human   257 VQVLSEGWATPLKGFMREKEYLQVMHFDTLLDGMALPDGVI--NMSIPIVLPVSAEDKTRLEGCS 319

  Fly   354 SLTLKYQGKAVAILRRPEFYFQRKEERLARQFGTSNPNHPYSKQVYESGDYLVGGDLAVIERIRW 418
            ...|.:.|:.|||||..|||..|||||.:|.:||:...||:.|.|.||||:||||||.|:|:|||
Human   320 KFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRW 384

  Fly   419 EDGLDQYRLTPNELRRRFKELNADAIFAFQLRNPIHNGHALLMQDTRRQLLERGFKQPVLLLHPL 483
            .||||||||||.||:::.||:||||:||||||||:|||||||||||||:|||||:|.||||||||
Human   385 NDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPL 449

  Fly   484 GGWTKDDDVPLDVRMKQHQAVLDAGVLRREDTVLAIFPSPMMYAGPTEVQWHAKARMNAGANFYI 548
            ||||||||||||.|||||.|||:.|||..:.|::|||||||:||||||||||.::||.|||||||
Human   450 GGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYI 514

  Fly   549 VGRDPAGMPHPAKETYPDGNLYDATHGARVLKMAQGLDSMEILPFRVAAYDKSASRMAFFEPKRK 613
            |||||||||||  ||..|  ||:.|||.:||.||.||.|:||:|||||||:|:...|.|::|.|.
Human   515 VGRDPAGMPHP--ETKKD--LYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARH 575

  Fly   614 DEFEFISGTKMRTLAKTGASPPDGFMEPEAWRILATYYQNLPQS 657
            :||:|||||:||.||:.|.:||||||.|:||::|..||::|.::
Human   576 NEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Papss	NP_730460.1	CysC	55..249	CDD:440295	127/193 (66%)
		ATPS	279..650	CDD:173895	247/373 (66%)
PAPSS2	NP_001015880.1	Adenylyl-sulfate kinase. /evidence=ECO:0000305	1..215		132/213 (62%)
		CysC	23..217	CDD:440295	127/193 (66%)
		ATPS	244..612	CDD:173895	247/373 (66%)