DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Papss and Papss1

DIOPT Version :9

Sequence 1:	NP_730460.1	Gene:	Papss / 40167	FlyBaseID:	FBgn0020389	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001381988.1	Gene:	Papss1 / 295443	RGDID:	1308081	Length:	624	Species:	Rattus norvegicus

Alignment Length:	617	Identity:	391/617 - (63%)
Similarity:	480/617 - (77%)	Gaps:	17/617 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LQVATNVTEQKHHVTRETRGKNLGLCRGFRGCTVWLTGLSGAGKTSIAFELEAYLVSRGIPAYGL 108
            :|.|||||.|.|||:|..||:.:|...||||||||||||||||||:::..||.|||..|||.|.|
  Rat    22 MQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTL 86

  Fly   109 DGDNIRTGLNKNLGFTPADREENIRRVGEVAKLFADSGVVAICSFVSPFADDREMARKIHKDAGL 173
            ||||||.||||||||:|.|||||:||:.||||||||:|:|.|.||:||:..||..||:||:.|.|
  Rat    87 DGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASL 151

  Fly   174 KFYEIFVDTPLDVCETRDVKGLYKKAREGVIKGFTGITQEYERPQMPELVVNTHGYTVRESTQKL 238
            .|:|:|||.||.|||.|||||||||||.|.|||||||..|||:|:.||||:.|....|.:..|::
  Rat   152 PFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQV 216

  Fly   239 VTLLEQEGIIPRSLRDVDL---LPELYPSESIATEALRHEAESLQAIEISTVELQWVQVLAEGWA 300
            |.||::..|:|     ||.   :.|||..|: .....:.:||:|.|::|:.|::|||||||||||
  Rat   217 VELLQERDIVP-----VDASYEVKELYVPEN-KLHLAKTDAEALPALKINKVDMQWVQVLAEGWA 275

  Fly   301 YPLRGFMREDEYLQTLHFNTLQSGMDGSYRENHSVPIVLSATQADKDRLDGCSSLTLKYQGKAVA 365
            .||.|||||.||||.|||:.|   :||.. .|.||||||:|||.||:|||||::..|.|:|:.||
  Rat   276 TPLNGFMREREYLQCLHFDCL---LDGGV-INLSVPIVLTATQEDKERLDGCTAFALVYEGRRVA 336

  Fly   366 ILRRPEFYFQRKEERLARQFGTSNPNHPYSKQVYESGDYLVGGDLAVIERIRWEDGLDQYRLTPN 430
            |||.|||:..|||||.|||:||:..:|||.|.:.|.||:|:||||.|::||.|.||||||||||.
  Rat   337 ILRNPEFFEHRKEERCARQWGTTCRSHPYIKMILEQGDWLIGGDLQVLDRIYWNDGLDQYRLTPA 401

  Fly   431 ELRRRFKELNADAIFAFQLRNPIHNGHALLMQDTRRQLLERGFKQPVLLLHPLGGWTKDDDVPLD 495
            ||:::||::||||:||||||||:|||||||||||.:||||||:::|||||||||||||||||||.
  Rat   402 ELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLM 466

  Fly   496 VRMKQHQAVLDAGVLRREDTVLAIFPSPMMYAGPTEVQWHAKARMNAGANFYIVGRDPAGMPHPA 560
            .|||||.|||:.|:|..|.||:||||||||||||||||||.:|||.||||||||||||||||||
  Rat   467 WRMKQHAAVLEEGILNPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHP- 530

  Fly   561 KETYPDGNLYDATHGARVLKMAQGLDSMEILPFRVAAYDKSASRMAFFEPKRKDEFEFISGTKMR 625
             ||..|  ||:.||||:||.||.||.::||:|||||||:|...||.:::....::|||||||:||
  Rat   531 -ETGKD--LYEPTHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSDHHEDFEFISGTRMR 592

  Fly   626 TLAKTGASPPDGFMEPEAWRILATYYQNLPQS 657
            .||:.|..||:|||.|:||.:|..||::|.::
  Rat   593 KLAREGQKPPEGFMAPKAWTVLVEYYKSLEKA 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Papss	NP_730460.1	APS_kinase	73..228	CDD:279865	109/154 (71%)
		sopT	270..648	CDD:273023	249/377 (66%)
		ATPS	279..650	CDD:173895	248/370 (67%)
Papss1	NP_001381988.1	APS_kinase	51..205	CDD:396247	108/153 (71%)
Papss1	NP_001381988.1	ATPS	254..617	CDD:173895	248/370 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349177
Domainoid	1	1.000	339	1.000	Domainoid score	I1065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81740
Inparanoid	1	1.050	789	1.000	Inparanoid score	I489
OMA	1	1.010	-	-		QHG52346
OrthoDB	1	1.010	-	-		D261243at33208
OrthoFinder	1	1.000	-	-		FOG0000913
OrthoInspector	1	1.000	-	-		otm45931
orthoMCL	1	0.900	-	-		OOG6_100343
Panther	1	1.100	-	-	O	PTHR11055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X525
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910