DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Papss and Papss2

DIOPT Version :9

Sequence 1:	NP_730460.1	Gene:	Papss / 40167	FlyBaseID:	FBgn0020389	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_006231336.1	Gene:	Papss2 / 294103	RGDID:	1307012	Length:	619	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	387/613 - (63%)
Similarity:	481/613 - (78%)	Gaps:	12/613 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QVATNVTEQKHHVTRETRGKNLGLCRGFRGCTVWLTGLSGAGKTSIAFELEAYLVSRGIPAYGLD 109
            |.:|||..|.|||:|..||:.:|...||||||||||||||||||:|:|.||.||||..||.|.||
  Rat    12 QKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLD 76

  Fly   110 GDNIRTGLNKNLGFTPADREENIRRVGEVAKLFADSGVVAICSFVSPFADDREMARKIHKDAGLK 174
            |||:|.||||||||:..||||||||:.||||||||:|:|.|.||:||||.|||.|||||:.|||.
  Rat    77 GDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLP 141

  Fly   175 FYEIFVDTPLDVCETRDVKGLYKKAREGVIKGFTGITQEYERPQMPELVVNTHGYTVRESTQKLV 239
            |:|||||.||::||:||||||||:||.|.|||||||...||:|:.||.|:.|:..:|.:..|::|
  Rat   142 FFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLKTNLSSVSDCVQQVV 206

  Fly   240 TLLEQEGIIPRSLRDVDLLPELYPSESIATEALRHEAESLQAIEISTVELQWVQVLAEGWAYPLR 304
            .||:::.|:|.:  .:..:.||:..|: ..:.:|.|.|:|.::.|:.::|||||:|:||||.||:
  Rat   207 ELLQEQSIVPHT--TIKGIHELFVPEN-KIDQIRAELETLPSLPITKLDLQWVQILSEGWATPLK 268

  Fly   305 GFMREDEYLQTLHFNTLQSGM---DGSYRENHSVPIVLSATQADKDRLDGCSSLTLKYQGKAVAI 366
            |||||.||||||||:||..|:   ||..  |.|:||||..:..||.||:|||...|.|:|:.||:
  Rat   269 GFMREKEYLQTLHFDTLLDGVILRDGVI--NMSIPIVLPVSGDDKARLEGCSKFALMYEGRRVAL 331

  Fly   367 LRRPEFYFQRKEERLARQFGTSNPNHPYSKQVYESGDYLVGGDLAVIERIRWEDGLDQYRLTPNE 431
            |:.||||..|||||.:|.:||::..||:.|.|.|.||:||||||.|:|||||.||||||||||.|
  Rat   332 LQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQYRLTPLE 396

  Fly   432 LRRRFKELNADAIFAFQLRNPIHNGHALLMQDTRRQLLERGFKQPVLLLHPLGGWTKDDDVPLDV 496
            |:::.|:::|||:||||||||:|||||||||||||:|||||:|.||||||||||||||||||||.
  Rat   397 LKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDW 461

  Fly   497 RMKQHQAVLDAGVLRREDTVLAIFPSPMMYAGPTEVQWHAKARMNAGANFYIVGRDPAGMPHPAK 561
            |||||.|||:.|:|..:.|::|||||||:||||||||||.:.||.||||||||||||||||||
  Rat   462 RMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHP-- 524

  Fly   562 ETYPDGNLYDATHGARVLKMAQGLDSMEILPFRVAAYDKSASRMAFFEPKRKDEFEFISGTKMRT 626
            ||..|  ||:.|||.:||.||.||.|:||:|||||||:|....|.|::|.|.|||:|||||:||.
  Rat   525 ETKKD--LYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDEFDFISGTRMRK 587

  Fly   627 LAKTGASPPDGFMEPEAWRILATYYQNL 654
            ||:.|..||||||.|:||::|..||::|
  Rat   588 LAREGEDPPDGFMAPKAWKVLTDYYRSL 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Papss	NP_730460.1	APS_kinase	73..228	CDD:279865	112/154 (73%)
		sopT	270..648	CDD:273023	247/380 (65%)
		ATPS	279..650	CDD:173895	245/373 (66%)
Papss2	XP_006231336.1	APSK	43..193	CDD:238985	108/149 (72%)
		sopT	225..610	CDD:273023	251/391 (64%)
		ATPS	243..611	CDD:173895	245/373 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349176
Domainoid	1	1.000	339	1.000	Domainoid score	I1065
eggNOG	1	0.900	-	-		E1_COG0529
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I489
OMA	1	1.010	-	-		QHG52346
OrthoDB	1	1.010	-	-		D261243at33208
OrthoFinder	1	1.000	-	-		FOG0000913
OrthoInspector	1	1.000	-	-		otm45931
orthoMCL	1	0.900	-	-		OOG6_100343
Panther	1	1.100	-	-	LDO	PTHR11055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X525
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810