back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Papss and Papss1

DIOPT Version :9

Sequence 1:	NP_730460.1	Gene:	Papss / 40167	FlyBaseID:	FBgn0020389	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_035993.1	Gene:	Papss1 / 23971	MGIID:	1330587	Length:	624	Species:	Mus musculus

Alignment Length:	617	Identity:	392/617 - (63%)
Similarity:	480/617 - (77%)	Gaps:	17/617 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LQVATNVTEQKHHVTRETRGKNLGLCRGFRGCTVWLTGLSGAGKTSIAFELEAYLVSRGIPAYGL 108
            :|.|||||.|.|||:|..||:.:|...||||||||||||||||||:::..||.|||..|||.|.|
Mouse    22 MQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTL 86

  Fly   109 DGDNIRTGLNKNLGFTPADREENIRRVGEVAKLFADSGVVAICSFVSPFADDREMARKIHKDAGL 173
            ||||||.||||||||:|.|||||:||:.||||||||:|:|.|.||:||:..||..||:||:.|.|
Mouse    87 DGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASL 151

  Fly   174 KFYEIFVDTPLDVCETRDVKGLYKKAREGVIKGFTGITQEYERPQMPELVVNTHGYTVRESTQKL 238
            .|:|:|||.||.|||.|||||||||||.|.|||||||..|||:|:.||||:.|....|.:..|::
Mouse   152 PFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQV 216

  Fly   239 VTLLEQEGIIPRSLRDVDL---LPELYPSESIATEALRHEAESLQAIEISTVELQWVQVLAEGWA 300
            |.||::..|:|     ||.   :.|||..|: .....:.:||:|.|::|:.|::|||||||||||
Mouse   217 VELLQERDIVP-----VDASYEVKELYVPEN-KLHLAKTDAEALPALKINKVDMQWVQVLAEGWA 275

  Fly   301 YPLRGFMREDEYLQTLHFNTLQSGMDGSYRENHSVPIVLSATQADKDRLDGCSSLTLKYQGKAVA 365
            .||.|||||.||||.|||:.|   :||.. .|.||||||:||..||:|||||::..|.|:|:.||
Mouse   276 TPLNGFMREREYLQCLHFDCL---LDGGV-INLSVPIVLTATHEDKERLDGCTAFALVYEGRRVA 336

  Fly   366 ILRRPEFYFQRKEERLARQFGTSNPNHPYSKQVYESGDYLVGGDLAVIERIRWEDGLDQYRLTPN 430
            |||.|||:..|||||.|||:||:..||||.|.|.|.||:|:||||.|::||.|.||||||||||.
Mouse   337 ILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVLEQGDWLIGGDLQVLDRIYWNDGLDQYRLTPT 401

  Fly   431 ELRRRFKELNADAIFAFQLRNPIHNGHALLMQDTRRQLLERGFKQPVLLLHPLGGWTKDDDVPLD 495
            ||:::||::||||:||||||||:|||||||||||.:||||||:::|||||||||||||||||||.
Mouse   402 ELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLM 466

  Fly   496 VRMKQHQAVLDAGVLRREDTVLAIFPSPMMYAGPTEVQWHAKARMNAGANFYIVGRDPAGMPHPA 560
            .|||||.|||:.|:|..|.||:||||||||||||||||||.:|||.||||||||||||||||||
Mouse   467 WRMKQHAAVLEEGILDPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHP- 530

  Fly   561 KETYPDGNLYDATHGARVLKMAQGLDSMEILPFRVAAYDKSASRMAFFEPKRKDEFEFISGTKMR 625
             ||..|  ||:.||||:||.||.||.::||:|||||||:|...||.:::.:..::|||||||:||
Mouse   531 -ETGKD--LYEPTHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFISGTRMR 592

  Fly   626 TLAKTGASPPDGFMEPEAWRILATYYQNLPQS 657
            .||:.|..||:|||.|:||.:|..||::|.::
Mouse   593 KLAREGQKPPEGFMAPKAWTVLVEYYKSLEKA 624

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.