DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and CDC42BPB

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_005268284.1	Gene:	CDC42BPB / 9578	HGNCID:	1738	Length:	1728	Species:	Homo sapiens

Alignment Length:	448	Identity:	184/448 - (41%)
Similarity:	249/448 - (55%)	Gaps:	87/448 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KQRLAKLEAQLKD-----------------------ESLSEAQRQEKR----LQHAQKETEYLRL 83
            |.||.|||..|.|                       |....|.|::|.    |:.|:..|:.  :
Human     4 KVRLKKLEQLLLDGPWRNESALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQL--V 66

  Fly    84 KRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEA 148
            |.::|..||||.:|||||||||||.:|:.|:|..:||||:|.|.:||::.:.|..|.||||||..
Human    67 KEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG 131

  Fly   149 DHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMK-KDTLSEEGTQFYISETALAIDSIHKLGF 212
            |.||:..::|:|||..:|||:|::..|||::|||.| :|.|.|:..:|||.|..|||||||:|.:
Human   132 DCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHY 196

  Fly   213 IHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKR 277
            :||||||||:|||..||::|:|||                                ||..|:...
Human   197 VHRDIKPDNVLLDVNGHIRLADFG--------------------------------SCLKMNDDG 229

  Fly   278 RAESWKRNRRALAYSTVGTPDYIAPEVF--LQTG---YGPACDWWSLGVIMYEMLMGYPPFCSDN 337
            ..:|      ::|   |||||||:||:.  ::.|   |||.||||||||.|||||.|..||.:::
Human   230 TVQS------SVA---VGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAES 285

  Fly   338 PQDTYRKVMNWRETLIFPPEI-PISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEH 401
            ..:||.|:||..|...||..: .:|||||:.|....|..:|||| |.|:||.|...||.|::||:
Human   286 LVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLG-QNGIEDFKKHAFFEGLNWEN 349

  Fly   402 IRERPAAIPVEVRSIDDTSNFDEFPDV--SLEIPSAPIPQGGEIAKDWV---FINYTY 454
            ||...|....:|.|..||||||...||  :.||    :|.|.......:   ||.:|:
Human   350 IRNLEAPYIPDVSSPSDTSNFDVDDDVLRNTEI----LPPGSHTGFSGLHLPFIGFTF 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	15/65 (23%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	167/376 (44%)
CDC42BPB	XP_005268284.1	STKc_MRCK_beta	3..411	CDD:270774	184/448 (41%)
		S_TKc	76..342	CDD:214567	140/307 (46%)
		TPH	426..786	CDD:290579
		KELK	528..606	CDD:292424
		DMPK_coil	878..939	CDD:117396
		C1	1043..1092	CDD:237996
		PH_MRCK	1102..1236	CDD:269949
		CNH	1262..1527	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920