DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and ROCK2

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_005246247.1	Gene:	ROCK2 / 9475	HGNCID:	10252	Length:	1417	Species:	Homo sapiens

Alignment Length:	444	Identity:	164/444 - (36%)
Similarity:	250/444 - (56%)	Gaps:	79/444 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GERKQRLAKLEAQLKD-------ESLSE------------AQRQEKRLQHAQKETEYL--RLKRL 86
            |..:||  ||||.::|       |||.:            |.|:.|.:.:.....|.:  :::.|
Human    23 GASRQR--KLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGL 85

  Fly    87 RLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQ 151
            ::..||::.:|||||||||||:||:.|.:..|||||:|.|.:|:::...|....|||::..|:..
Human    86 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSP 150

  Fly   152 WVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRD 216
            |||:::|:|||...||::||::||||::.|:...| :.|:..:||.:|..||:|:||.:|.||||
Human   151 WVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHSMGLIHRD 214

  Fly   217 IKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAES 281
            :||||:|||..|||||:|||.|..:.::                     ..:.|.
Human   215 VKPDNMLLDKHGHLKLADFGTCMKMDET---------------------GMVHCD---------- 248

  Fly   282 WKRNRRALAYSTVGTPDYIAPEVFLQTG----YGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTY 342
                      :.|||||||:|||....|    ||..|||||:||.:||||:|..||.:|:...||
Human   249 ----------TAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTY 303

  Fly   343 RKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVD--WEHIRER 405
            .|:|:.:.:|.||.:..||:.||..|..|..:.:.||| :.|:|:::..|||:...  |::|||.
Human   304 SKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLG-RNGVEEIRQHPFFKNDQWHWDNIRET 367

  Fly   406 PAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQ---GGEIAKDWVFINYTYKR 456
            .|.:..|:.|..|:||||:..|...::.:.|||:   |.::.    ||.:||.|
Human   368 AAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLP----FIGFTYYR 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	15/62 (24%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	146/372 (39%)
ROCK2	XP_005246247.1	STKc_ROCK2	39..417	CDD:270771	155/424 (37%)
		S_TKc	92..354	CDD:214567	122/304 (40%)
		SCP-1	412..1080	CDD:114219	3/6 (50%)
		HR1_ROCK2	505..571	CDD:212028
		Rho_Binding	979..1046	CDD:286056
		PH_ROCK	1151..1257	CDD:269948
		C1	1261..1307	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920