DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and CBK1

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_014238.3	Gene:	CBK1 / 855561	SGDID:	S000005105	Length:	756	Species:	Saccharomyces cerevisiae

Alignment Length:	474	Identity:	236/474 - (49%)
Similarity:	320/474 - (67%)	Gaps:	39/474 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYLRLK 84
            |.|||...|:.:||:|.:.|....||.:|..:||.:|...:.||.::..:.....:||:::|||:
Yeast   279 TQDKAAAVKLKIENFYQSSVKYAIERNERRVELETELTSHNWSEERKSRQLSSLGKKESQFLRLR 343

  Fly    85 RLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEAD 149
            |.||.:|||..:||||:|||||||||||||||.:||||.|.|::|.:|:|:|||:||||||..:|
Yeast   344 RTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSD 408

  Fly   150 HQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIH 214
            ..|||.:||||||...||||||||||||:||:|::....:|:.|:||::|..|||::||||||||
Yeast   409 SPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIH 473

  Fly   215 RDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQ--------AKPSDFIGTCA----- 266
            |||||||:|:|.|||:|||||||.||..|:|.:::|:.|.|        :||..:.....
Yeast   474 RDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPGTYNANTTDTANK 538

  Fly   267 -------SLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMY 324
                   |:|.: |.::::.::|:::||.:||||||||||||||:||..|||..|||||||.|||
Yeast   539 RQTMVVDSISLT-MSNRQQIQTWRKSRRLMAYSTVGTPDYIAPEIFLYQGYGQECDWWSLGAIMY 602

  Fly   325 EMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLK 389
            |.|:|:|||||:.||:||||:||:.:||.||.:|.||.||::.|......||:|||...|.:::|
Yeast   603 ECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIK 667

  Fly   390 SVPFFRGVDWEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLE-IPSAP------------IPQGG 441
            |.||||||||..||:..|....::.||.|| .|  ||...|| :|.:|            ..|||
Yeast   668 SHPFFRGVDWNTIRQVEAPYIPKLSSITDT-RF--FPTDELENVPDSPAMAQAAKQREQMTKQGG 729

  Fly   442 E--IAKDWVFINYTYKRFE 458
            .  :.:|..||.|||.||:
Yeast   730 SAPVKEDLPFIGYTYSRFD 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	22/64 (34%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	208/398 (52%)
CBK1	NP_014238.3	STKc_NDR_like_fungal	350..748	CDD:270778	210/401 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346105
Domainoid	1	1.000	219	1.000	Domainoid score	I466
eggNOG	1	0.900	-	-		E1_KOG0605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	455	1.000	Inparanoid score	I246
Isobase	1	0.950	-	0	Normalized mean entropy	S373
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		oto98945
orthoMCL	1	0.900	-	-		OOG6_100850
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R870
SonicParanoid	1	1.000	-	-		X595
TreeFam	1	0.960	-	-
	14	13.730