DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Rock1

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001376168.1	Gene:	Rock1 / 81762	RGDID:	620424	Length:	1354	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	157/403 - (38%)
Similarity:	233/403 - (57%)	Gaps:	60/403 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AQRQEKRLQH---AQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLR 125
            |.|:.|.:.:   ..|:| ..:::.||:..||:|.:|||||||||||:||:.|.|..|||||:|.
  Rat    45 ALRKNKNIDNFLSRYKDT-INKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLS 108

  Fly   126 KADMLEKEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSE 190
            |.:|:::...|....|||::..|:..|||:::|:|||...||::||::||||::.|:...| :.|
  Rat   109 KFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPE 172

  Fly   191 EGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQ 255
            :..:||.:|..||:|:||.:||||||:||||:|||..|||||:|||.|..:.|.
  Rat   173 KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKE----------- 226

  Fly   256 AKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTG----YGPACDW 316
                      ..:.|.                    :.|||||||:|||....|    ||..|||
  Rat   227 ----------GMVRCD--------------------TAVGTPDYISPEVLKSQGGDGYYGRECDW 261

  Fly   317 WSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGS 381
            ||:||.:||||:|..||.:|:...||.|:||.:.:|.||.:..||:|||..|..|..:.:.|||
  Rat   262 WSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLG- 325

  Fly   382 QRGLEDLKSVPFFRGVD--WEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQ---GG 441
            :.|:|::|...||:...  ||.:|:..|.:..::.|..||||||:..:...:..:.|||:   |.
  Rat   326 RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGN 390

  Fly   442 EIAKDWVFINYTY 454
            ::.    |:.:||
  Rat   391 QLP----FVGFTY 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	5/23 (22%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	150/373 (40%)
Rock1	NP_001376168.1	STKc_ROCK1	2..406	CDD:270772	157/403 (39%)
		Interaction with FHOD1. /evidence=ECO:0000250	368..727		9/36 (25%)
		SMC_prok_B	426..>1097	CDD:274008
		HR1_ROCK1	489..554	CDD:212029
		SHROOM3 binding. /evidence=ECO:0000250\|UniProtKB:Q13464	707..946
		ROCK_SBD	836..913	CDD:409019
		RHOA binding. /evidence=ECO:0000250	998..1010
		PH_ROCK	1119..1225	CDD:269948
		C1_ROCK1	1222..1290	CDD:410424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920