DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trc and ROCK1

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_005397.1	Gene:	ROCK1 / 6093	HGNCID:	10251	Length:	1354	Species:	Homo sapiens

Alignment Length:	403	Identity:	158/403 - (39%)
Similarity:	233/403 - (57%)	Gaps:	60/403 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AQRQEKRLQH---AQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLR 125
            |.|:.|.:.:   ..|:| ..:::.||:..||:|.:|||||||||||:||:.|.|..|||||:|.
Human    45 ALRKNKNIDNFLSRYKDT-INKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLS 108

  Fly   126 KADMLEKEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSE 190
            |.:|:::...|....|||::..|:..|||:::|:|||...||::||::||||::.|:...| :.|
Human   109 KFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPE 172

  Fly   191 EGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQ 255
            :..:||.:|..||:|:||.:||||||:||||:|||..|||||:|||.|..:.|.
Human   173 KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKE----------- 226

  Fly   256 AKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTG----YGPACDW 316
                      ..:.|.                    :.|||||||:|||....|    ||..|||
Human   227 ----------GMVRCD--------------------TAVGTPDYISPEVLKSQGGDGYYGRECDW 261

  Fly   317 WSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGS 381
            ||:||.:||||:|..||.:|:...||.|:||.:.:|.||.:..||:|||..|..|..:.:.|||
Human   262 WSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLG- 325

  Fly   382 QRGLEDLKSVPFFRGVD--WEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQ---GG 441
            :.|:|::|...||:...  ||.:|:..|.:..::.|..||||||:..:...|..:.|||:   |.
Human   326 RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGN 390

  Fly   442 EIAKDWVFINYTY 454
            ::.    |:.:||
Human   391 QLP----FVGFTY 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	5/23 (22%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	151/373 (40%)
ROCK1	NP_005397.1	STKc_ROCK1	2..406	CDD:270772	158/403 (39%)
		S_TKc	76..338	CDD:214567	128/304 (42%)
		Interaction with FHOD1. /evidence=ECO:0000269\|PubMed:18694941	368..727		10/36 (28%)
		SbcC	<422..1027	CDD:223496
		HR1_ROCK1	489..554	CDD:212029
		SHROOM3 binding. /evidence=ECO:0000269\|PubMed:22493320	707..946
		Rho_Binding	949..1014	CDD:286056
		RHOA binding	998..1010
		Auto-inhibitory	1115..1354
		PH_ROCK	1119..1225	CDD:269948
		C1	1229..1275	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920