DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Mast1

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_064329.2	Gene:	Mast1 / 56527	MGIID:	1861901	Length:	1570	Species:	Mus musculus

Alignment Length:	345	Identity:	120/345 - (34%)
Similarity:	186/345 - (53%)	Gaps:	40/345 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWV 153
            |..||:.:|:|..||:|.|.||:.:||...:|||.:.|.:::.:.|:.....|||:|..|::.:|
Mouse   372 GESDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFV 436

  Fly   154 VKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIK 218
            |.|:.||:...:|.::||::.|||..|||.....|..|..:.|.:||.||::.:|..|.:|||:|
Mouse   437 VGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLK 501

  Fly   219 PDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAESWK 283
            |||||:.:.||:||:||||......|..|:.|....:                           |
Mouse   502 PDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIE---------------------------K 539

  Fly   284 RNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNW 348
            ..|..|.....|||:||||||.|:.|||...|||::|:|:||.|:|..||..|.|::.:.:|::
Mouse   540 DAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVIS- 603

  Fly   349 RETLIFPPEIPISEEAKET----IINFCCEADR--RLGSQRGLEDLKSVPFFRGVDWEHIRERPA 407
             :.:::|.    .:||..|    :|:...:.:.  |||: .|..::|...|||.:||..:..:.|
Mouse   604 -DDILWPE----GDEALPTDAQLLISSLLQTNPLVRLGA-GGAFEVKQHSFFRDLDWTGLLRQKA 662

  Fly   408 AIPVEVRSIDDTSNFDEFPD 427
            .....:.|.||||.||...|
Mouse   663 EFIPHLESEDDTSYFDTRSD 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	119/343 (35%)
Mast1	NP_064329.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..80
		DUF1908	61..337	CDD:401031
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..171
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..377		2/4 (50%)
		STKc_MAST	375..654	CDD:270760	108/312 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..885
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..911
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..967
		PDZ_signaling	970..1052	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1061..1186
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1294
		PHA03247	<1205..1566	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1308..1570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0605
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900