DRSC/TRiP Functional Genomics Resources

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Protein Alignment trc and PRKG2

DIOPT Version :10

Sequence 1:NP_001262071.1 Gene:trc / 40165 FlyBaseID:FBgn0003744 Length:463 Species:Drosophila melanogaster
Sequence 2:NP_006250.1 Gene:PRKG2 / 5593 HGNCID:9416 Length:762 Species:Homo sapiens


Alignment Length:405 Identity:117/405 - (28%)
Similarity:199/405 - (49%) Gaps:69/405 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 LENYYSNL----VTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYLRLKRLRLGVE 91
            ||.|.:||    ..::.:|.....||...|   ||...|.:||..:.:....           .:
Human   401 LEGYVANLNRDDEKRHAKRSMSNWKLSKAL---SLEMIQLKEKVARFSSSSP-----------FQ 451

  Fly    92 DFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKM 156
            :.|.:..:|.|.||.|.||:.|:....:|||.:||..:::.:|..||.:|:.:|.|....::||:
Human   452 NLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKL 516

  Fly   157 YYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDN 221
            |.:|:|...:|:::|...||::.::|..:.:..|..::|.::....|.|.:|:||.|:||:||:|
Human   517 YRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPEN 581

  Fly   222 LLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAESWKRNR 286
            |:|||.|:|||.|||....:....:|                                       
Human   582 LILDAEGYLKLVDFGFAKKIGSGQKT--------------------------------------- 607

  Fly   287 RALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRET 351
                ::..|||:|:||||.|..|:..:.|:||||:::||:|.|.|||...:...||..::...|.
Human   608 ----WTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEK 668

  Fly   352 LIFPPEIPISEEAKETIINFCCEAD--RRLGS-QRGLEDLKSVPFFRGVDWEHIRER--PAAIPV 411
            :.||.:|   ....|.:|...|..:  .|||: :.|:.|:|...:..|.:||.::.|  |:.:..
Human   669 MDFPRKI---TRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQR 730

  Fly   412 EVRSIDDTSNFDEFP 426
            |::...|.|.||::|
Human   731 ELKGPIDHSYFDKYP 745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trcNP_001262071.1 MobB_Trc-like 24..88 CDD:439274 14/60 (23%)
STKc_NDR_like 91..455 CDD:270750 103/341 (30%)
PRKG2NP_006250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 117..138
cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000305|PubMed:26769964 168..283
CAP_ED 168..277 CDD:237999
cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000305|PubMed:26769964 286..416 5/14 (36%)
CAP_ED 286..401 CDD:237999 117/405 (29%)
STKc_cGK 459..718 CDD:270724 93/304 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 740..762 3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

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