DRSC/TRiP Functional Genomics Resources

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Protein Alignment trc and PRKCI

DIOPT Version :10

Sequence 1:NP_001262071.1 Gene:trc / 40165 FlyBaseID:FBgn0003744 Length:463 Species:Drosophila melanogaster
Sequence 2:NP_002731.4 Gene:PRKCI / 5584 HGNCID:9404 Length:596 Species:Homo sapiens


Alignment Length:377 Identity:124/377 - (32%)
Similarity:194/377 - (51%) Gaps:72/377 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 LGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEA-DHQ 151
            ||::||:.|:|||||::.:|.||:.|.|..:|||||::|..:.:.|.:..|:.|:.|..:| :|.
Human   249 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP 313

  Fly   152 WVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRD 216
            ::|.::..||....|:.::|::.|||:|..:.::..|.||..:||.:|.:||::.:|:.|.|:||
Human   314 FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRD 378

  Fly   217 IKPDNLLLDARGHLKLSDFGLC-TGLKKSHRTDFYRDLSQAKPSDFIGT-CASLSCSPMDSKRRA 279
            :|.||:|||:.||:||:|:|:| .||               :|.|...| |              
Human   379 LKLDNVLLDSEGHIKLTDYGMCKEGL---------------RPGDTTSTFC-------------- 414

  Fly   280 ESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPF----CSDNP-Q 339
                           |||:|||||:.....||.:.|||:|||:|:||:.|..||    .|||| |
Human   415 ---------------GTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQ 464

  Fly   340 DTYRKVMNWRETLIFPP------EIP--ISEEAKETIINFC-CEADRRLG--SQRGLEDLKSVPF 393
            :|        |..:|..      .||  :|.:|...:.:|. .:...|||  .|.|..|::..||
Human   465 NT--------EDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF 521

  Fly   394 FRGVDWEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQGGEIAK 445
            ||.|||: :.|:...:|....:|......|.|.......|....|...:|.:
Human   522 FRNVDWD-MMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVR 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trcNP_001262071.1 MobB_Trc-like 24..88 CDD:439274 124/377 (33%)
STKc_NDR_like 91..455 CDD:270750 122/374 (33%)
PRKCINP_002731.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Regulatory domain 2..253 2/3 (67%)
Required for interaction with RAB2 2..28
PB1_aPKC 26..108 CDD:99725
Interaction with PARD6A 72..91
Pseudosubstrate. /evidence=ECO:0000250 125..134
C1_aPKC 139..193 CDD:410344
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 220..246
STKc_aPKC_iota 233..596 CDD:270769 124/377 (33%)
Blue background indicates that the domain is not in the aligned region.

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