DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trc and Lats2

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_056586.2	Gene:	Lats2 / 50523	MGIID:	1354386	Length:	1042	Species:	Mus musculus

Alignment Length:	452	Identity:	197/452 - (43%)
Similarity:	280/452 - (61%)	Gaps:	31/452 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYLRLKRLRLGVED 92
            |..:|.:..|::..|.::..|..:||.::....|.||::::.|....|||:.|.||||.::....
Mouse   561 KFFMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSM 625

  Fly    93 FEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMY 157
            |..:|.:|.||||||.|..|.||..:||||.|||.|:|.:.|||||:||||:|.|||::||||:|
Mouse   626 FVKIKTLGIGAFGEVCLACKLDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLY 690

  Fly   158 YSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNL 222
            |||||..:||.:|:::||||||:||::.:...|...:|||:|..|||:|:||:|||||||||||:
Mouse   691 YSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNI 755

  Fly   223 LLDARGHLKLSDFGLCTGLKKSHRTDFYRD-----LSQAKPSDFIGTCASLSCSPMDSKRRAESW 282
            |:|..||:||:|||||||.:.:|.:.:|:.     ....:|.|.....::..|..........:.
Mouse   756 LIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQ 820

  Fly   283 KRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMN 347
            |:::|.||:|.||||:||||||.|:.||...|||||:|||::|||:|.|||.:..|.:|..||:|
Mouse   821 KQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVIN 885

  Fly   348 WRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEH-IRERPAAIPV 411
            |..||..|.::.:|.||::.|...||.||.||| :.|.:|||:.|||..:|:.. ||::||....
Mouse   886 WESTLHIPTQVRLSAEARDLITKLCCAADCRLG-RDGADDLKAHPFFNTIDFSRDIRKQPAPYVP 949

  Fly   412 EVRSIDDTSNFDEFPDVSLEIPSAPIP---QGGEIAKDW-------------VFINYTYKRF 457
            .:....||||||...:.|        |   ..||.||.|             .|..:|::||
Mouse   950 TISHPMDTSNFDPVDEES--------PWHEASGESAKAWDTLASPSSKHPEHAFYEFTFRRF 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	17/56 (30%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	176/385 (46%)
Lats2	NP_056586.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..44
		UBA_LATS2	100..140	CDD:270581
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..282
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..481
		PPxY motif	472..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..550
		PKc_like	624..1004	CDD:304357	178/389 (46%)
		S_TKc	626..931	CDD:214567	154/305 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1014..1042
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920