DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and stk38a

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_998621.1	Gene:	stk38a / 406765	ZFINID:	ZDB-GENE-040426-2811	Length:	468	Species:	Danio rerio

Alignment Length:	462	Identity:	322/462 - (69%)
Similarity:	387/462 - (83%)	Gaps:	18/462 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MSSRTQDADGASIRFSDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQR 66
            |:|:|..:.     .|:||.::.|.|||||||:||||::|:.||:.|..|||..:..|.|::.::
Zfish     3 MTSQTTCSS-----MSNHTKERVTMAKVTLENFYSNLISQHEEREMRQQKLEKVMDQEGLADEEK 62

  Fly    67 QEKRLQHAQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLE 131
            :.:|.:||:||||:|||||.|||:||||:|||||||||||||||||||||||||||:||||||||
Zfish    63 RLRRSEHARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLE 127

  Fly   132 KEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFY 196
            ||||.|:|||||:|||||..|||||:|||||.:||||||||||||||||||||||||:||.||||
Zfish   128 KEQVGHIRAERDILVEADSLWVVKMFYSFQDKMNLYLIMEFLPGGDMMTLLMKKDTLTEEATQFY 192

  Fly   197 ISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDF 261
            |:||.|||||||:||||||||||||||||:|||:|||||||||||||:|||:|||:|:.:.||||
Zfish   193 IAETVLAIDSIHQLGFIHRDIKPDNLLLDSRGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF 257

  Fly   262 IGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEM 326
                   :...|:|||:||:||||||.||:||||||||||||||:|.||...|||||||||||||
Zfish   258 -------TFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQNGYNKLCDWWSLGVIMYEM 315

  Fly   327 LMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSV 391
            |:|||||||:.||:|||||||||||||||||:||||:||:.|:.||||.:.|:|: .|:|::|:.
Zfish   316 LIGYPPFCSETPQETYRKVMNWRETLIFPPEVPISEKAKDLILRFCCEGEHRIGA-TGVEEIKTN 379

  Fly   392 PFFRGVDWEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQGGEI-----AKDWVFIN 451
            .||.|||::||||||||||:|::|||||||||||||..:..|||........     :|||||||
Zfish   380 AFFEGVDYDHIRERPAAIPIEIKSIDDTSNFDEFPDSDILQPSATTVVSNHTEADLKSKDWVFIN 444

  Fly   452 YTYKRFE 458
            |||||||
Zfish   445 YTYKRFE 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	34/68 (50%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	275/368 (75%)
stk38a	NP_998621.1	STKc_NDR1	87..464	CDD:270777	280/373 (75%)
stk38a	NP_998621.1	S_TKc	89..382	CDD:214567	232/300 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594831
Domainoid	1	1.000	482	1.000	Domainoid score	I392
eggNOG	1	0.900	-	-		E1_KOG0605
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56033
Inparanoid	1	1.050	667	1.000	Inparanoid score	I725
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216969at33208
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm25356
orthoMCL	1	0.900	-	-		OOG6_100850
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R870
SonicParanoid	1	1.000	-	-		X595
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790