DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Lats1

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001128015.2	Gene:	Lats1 / 308265	RGDID:	1564085	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	449	Identity:	188/449 - (41%)
Similarity:	281/449 - (62%)	Gaps:	24/449 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYLRLKRLRLGVED 92
            |..:|.:..|::..:.:|..|..:||.::....||:..:.:.|....|||:.|:||||.::....
  Rat   640 KFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSM 704

  Fly    93 FEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMY 157
            |..:|.:|.||||||.|.:|.||..:||.|.|||.|:|.:.|||||:||||:|.|||::|||::|
  Rat   705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLY 769

  Fly   158 YSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNL 222
            |||||..|||.:|:::||||||:||::.....|...:|||:|...|::|:||:|||||||||||:
  Rat   770 YSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGFIHRDIKPDNI 834

  Fly   223 LLDARGHLKLSDFGLCTGLKKSHRTDFYR--DLSQAKPSDFI---GTCASLSC----SPMDSKRR 278
            |:|..||:||:|||||||.:.:|.:.:|:  |..:....||.   |..::..|    .|::  ||
  Rat   835 LIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSSEWGDPSNCRCGDRLKPLE--RR 897

  Fly   279 AESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYR 343
            |.  ::::|.||:|.||||:||||||.|:|||...|||||:|||::|||:|.|||.:..|.:|..
  Rat   898 AA--RQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM 960

  Fly   344 KVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDW-EHIRERPA 407
            ||:||:.:|..||:..:|.||.:.||..|...:.||| :.|.:::|:.|||:.:|: ..:|::.|
  Rat   961 KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLG-KNGADEIKAHPFFKTIDFSSDLRQQSA 1024

  Fly   408 AIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQGGEIAKDW---------VFINYTYKRF 457
            :...::....||||||......|...........:....|         .|..:|::||
  Rat  1025 SYIPKITHPTDTSNFDPVDPDKLWSDGNEEENINDTLNGWYKNGKHPEHAFYEFTFRRF 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	16/56 (29%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	168/382 (44%)
Lats1	NP_001128015.2	UBA_like_SF	103..143	CDD:419673
		PHA03247	<183..590	CDD:223021
		STKc_LATS1	703..1084	CDD:270775	170/386 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920