DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Lats2

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001100737.1	Gene:	Lats2 / 305922	RGDID:	1305906	Length:	1042	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	196/452 - (43%)
Similarity:	279/452 - (61%)	Gaps:	31/452 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYLRLKRLRLGVED 92
            |..:|.:..|::..|.::..|..:||.::....|.|.::::.|....|||:.|.||||.::....
  Rat   561 KFFMEQHVENVIKTYQQKVSRRLQLEQEMAKAGLCETEQEQMRKILYQKESNYNRLKRAKMDKSM 625

  Fly    93 FEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMY 157
            |..:|.:|.||||||.|..|.||..:||||.|||.|:|.:.|||||:||||:|.|||::||||:|
  Rat   626 FVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLY 690

  Fly   158 YSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNL 222
            |||||..:||.:|:::||||||:||::.:...|...:|||:|..|||:|:||:|||||||||||:
  Rat   691 YSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNI 755

  Fly   223 LLDARGHLKLSDFGLCTGLKKSHRTDFYRD-----LSQAKPSDFIGTCASLSCSPMDSKRRAESW 282
            |:|..||:||:|||||||.:.:|.:.:|:.     ....:|.|.....::..|..........:.
  Rat   756 LIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPGDLWDDVSNCRCGDRLKTLEQRAQ 820

  Fly   283 KRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMN 347
            |:::|.||:|.||||:||||||.|:.||...|||||:|||::|||:|.|||.:..|.:|..||:|
  Rat   821 KQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVIN 885

  Fly   348 WRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEH-IRERPAAIPV 411
            |..||..|.::.:|.||::.|...||.||.||| :.|.:|||:.|||..:|:.. ||::||....
  Rat   886 WENTLHIPTQVKLSAEARDLITKLCCAADCRLG-RDGADDLKAHPFFSTIDFSRDIRKQPAPYVP 949

  Fly   412 EVRSIDDTSNFDEFPDVSLEIPSAPIP---QGGEIAKDW-------------VFINYTYKRF 457
            .:....||||||...:.|        |   ..||.||.|             .|..:|::||
  Rat   950 TISHPMDTSNFDPVDEES--------PWHEASGESAKAWDTLASPNSKHPEHAFYEFTFRRF 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	16/56 (29%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	176/385 (46%)
Lats2	NP_001100737.1	UBA_LATS2	101..141	CDD:270581
		PHA03247	<143..490	CDD:223021
		PKc_like	624..1004	CDD:419665	178/389 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920