DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and orb6

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_593165.1	Gene:	orb6 / 2543441	PomBaseID:	SPAC821.12	Length:	469	Species:	Schizosaccharomyces pombe

Alignment Length:	454	Identity:	224/454 - (49%)
Similarity:	303/454 - (66%)	Gaps:	21/454 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FSDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEY 80
            |...||||..|.|..:|:||...|....||.||...||.:|..|..||.::..:.....:||:::
pombe    16 FPKSTLDKVQKTKKYIEHYYKVAVDHAVERNQRRINLEQRLATERGSEERKNRQLRASGEKESQF 80

  Fly    81 LRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVL 145
            ||.:|.||.:|||..:||||:|||||||||||.|||.:||||.|.|.:|.:::|:|||:||||:|
pombe    81 LRFRRTRLSLEDFSTIKVIGKGAFGEVRLVQKLDTGKIYAMKSLLKTEMFKRDQLAHVKAERDLL 145

  Fly   146 VEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKL 210
            ||:|..|||.:||:|||.:.||||||||||||:||:|:..||.||:.|:||::|..|||..:|::
pombe   146 VESDSPWVVSLYYAFQDSLYLYLIMEFLPGGDLMTMLINYDTFSEDVTRFYMAECVLAIADVHRM 210

  Fly   211 GFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFI--GTCASLSCSPM 273
            |:|||||||||:|:|..||:|||||||.||..|..::..|   .:.:..:.:  |.........|
pombe   211 GYIHRDIKPDNILIDRDGHIKLSDFGLSTGFYKQDQSASY---MKPRTGNTVKRGQMVDAIWLTM 272

  Fly   274 DSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNP 338
            .||.:..:||:|||.:||||||||||||||:|||.|||..|||||||.||:|.|:|:|||||:|.
pombe   273 SSKDKMATWKKNRRVMAYSTVGTPDYIAPEIFLQQGYGQDCDWWSLGAIMFECLIGWPPFCSENS 337

  Fly   339 QDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEHIR 403
            .:||||::||||||.||.:|.:|.||::.:.....:::.||| :.|..::...|||.|:||:|||
pombe   338 HETYRKIINWRETLTFPNDIHLSIEARDLMDRLMTDSEHRLG-RGGAIEIMQHPFFTGIDWDHIR 401

  Fly   404 ERPAAIPVEVRSIDDTSNF--DEFPDVSLEIPSAPI--------PQGGEIAKDWVFINYTYKRF 457
            |..|.....::||.||..|  ||..    ::|..|:        ||..| ..:..|:.||||:|
pombe   402 ETAAPFIPNLKSITDTHYFPVDELE----QVPEQPVTQQPASVDPQTLE-QTNLAFLGYTYKKF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	25/68 (37%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	193/375 (51%)
orb6	NP_593165.1	STKc_NDR_like_fungal	91..461	CDD:270778	196/379 (52%)
orb6	NP_593165.1	S_TKc	93..392	CDD:214567	166/302 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	341	1.000	Domainoid score	I189
eggNOG	1	0.900	-	-		E1_KOG0605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I312
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		oto100422
orthoMCL	1	0.900	-	-		OOG6_100850
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R870
SonicParanoid	1	1.000	-	-		X595
TreeFam	1	0.960	-	-
	12	11.850