DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Cdc42bpg

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001028514.1	Gene:	Cdc42bpg / 240505	MGIID:	2652845	Length:	1551	Species:	Mus musculus

Alignment Length:	452	Identity:	170/452 - (37%)
Similarity:	249/452 - (55%)	Gaps:	77/452 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KQRLAKLEAQLKDES-------------------LSEA--QRQEKRLQHAQKETEYL-RLKRLRL 88
            :|||..||..::.|:                   ||.|  :|:....|.....:.:: ::|.|||
Mouse     2 EQRLRALEQLVRGEAGGSPGLDGLLDLLLGVHQELSSAPLRRERNVAQFLSWASPFVTKVKELRL 66

  Fly    89 GVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWV 153
            ..:|||.||||||||||||.:|:::.:|.::|||:|.|.:||::.:.|..|.||||||:.|.:||
Mouse    67 QRDDFEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWV 131

  Fly   154 VKMYYSFQDPVNLYLIMEFLPGGDMMTLLMK-KDTLSEEGTQFYISETALAIDSIHKLGFIHRDI 217
            ..::|:|||...|||:|::..|||::|||.: :|.|..|..|||::|..|||.|:|:||::|||:
Mouse   132 TALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDV 196

  Fly   218 KPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAESW 282
            ||||:|||..||::|:|||.|..|..:...|                 :|::
Mouse   197 KPDNILLDMNGHIRLADFGSCLRLNNNGMVD-----------------SSVA------------- 231

  Fly   283 KRNRRALAYSTVGTPDYIAPEVF--LQTG---YGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTY 342
                       |||||||:||:.  ::.|   |||.||||||||..||:|.|..||.:::..:||
Mouse   232 -----------VGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETY 285

  Fly   343 RKVMNWRETLIFPPEI-PISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEHIRERP 406
            .|:||..:.|.||.:: .:...|::.|....|..:.||| :.||:|.:..|||.|||||.:....
Mouse   286 GKIMNHEDHLQFPADVTDVPASAQDLIRQLLCRQEERLG-RGGLDDFRKHPFFEGVDWERLATST 349

  Fly   407 AAIPVEVRSIDDTSNFDEFPDVSLEIPSA--PIPQGGEIAKDWVFINYTY---KRFEVRNLE 463
            |....|:|...|||||| ..|.:|..|..  |...|........|:.:||   ..|:|::.|
Mouse   350 APYIPELRGPMDTSNFD-VDDDTLNRPETLPPSSHGAFSGHHLPFVGFTYTSGSPFDVQSSE 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	11/60 (18%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	152/375 (41%)
Cdc42bpg	NP_001028514.1	STKc_DMPK_like	69..399	CDD:270748	151/372 (41%)
		S_TKc	71..337	CDD:214567	127/307 (41%)
		Taxilin	452..774	CDD:286771
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..605
		DMPK_coil	743..798	CDD:117396
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	820..886
		C1_1	878..926	CDD:278556
		PH_MRCK	937..1069	CDD:269949
		CNH	1096..1359	CDD:279162
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1441..1551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920