DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Stk38l

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_006507092.1	Gene:	Stk38l / 232533	MGIID:	1922250	Length:	477	Species:	Mus musculus

Alignment Length:	457	Identity:	316/457 - (69%)
Similarity:	386/457 - (84%)	Gaps:	17/457 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GASIRF--SDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQH 73
            ||:..|  |:||.::.|.||:||||:||||:.|:.||:.|..|||..:::|.|::.:::.:|.||
Mouse    12 GATTTFPMSNHTRERVTVAKLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQH 76

  Fly    74 AQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHV 138
            |:||||:|||||.|||::|||:||||||||||||||||||||||:||||:||||||||||||||:
Mouse    77 ARKETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHI 141

  Fly   139 RAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALA 203
            |||||:|||||..|||||:|||||..||||||||||||||||||||||||:||.||||||||.||
Mouse   142 RAERDILVEADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLA 206

  Fly   204 IDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASL 268
            ||:||:|||||||:|||||||||:||:|||||||||||||:|||:|||:|:...||||
Mouse   207 IDAIHQLGFIHRDVKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDF------- 264

  Fly   269 SCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPF 333
            |...|:|||:||:||:|||.|||||||||||||||||:||||...||||||||||||||:|:|||
Mouse   265 SFQNMNSKRKAETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGFPPF 329

  Fly   334 CSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVD 398
            ||:.||:||||||:|:|||.||||:|:||:||:.|:.||.:::.|:|: .|:|::|..|||.|||
Mouse   330 CSETPQETYRKVMSWKETLAFPPEVPVSEKAKDLILRFCTDSENRIGN-GGVEEIKGHPFFEGVD 393

  Fly   399 WEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSA----PIPQGGE---IAKDWVFINYTYKR 456
            |.||||||||||:|:||||||||||:||:..:..|.|    .:|...|   .:|||||:||||||
Mouse   394 WGHIRERPAAIPIEIRSIDDTSNFDDFPESDILQPVAFFLFLVPNTTEPDYKSKDWVFLNYTYKR 458

  Fly   457 FE 458
            ||
Mouse   459 FE 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	35/70 (50%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	269/370 (73%)
Stk38l	XP_006507092.1	STKc_NDR2	93..465	CDD:270776	274/376 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849250
Domainoid	1	1.000	476	1.000	Domainoid score	I432
eggNOG	1	0.900	-	-		E1_KOG0605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I761
Isobase	1	0.950	-	0	Normalized mean entropy	S373
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216969at33208
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm42347
orthoMCL	1	0.900	-	-		OOG6_100850
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R870
SonicParanoid	1	1.000	-	-		X595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.640