DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Cdc42bpa

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_017175608.1	Gene:	Cdc42bpa / 226751	MGIID:	2441841	Length:	1810	Species:	Mus musculus

Alignment Length:	419	Identity:	175/419 - (41%)
Similarity:	241/419 - (57%)	Gaps:	72/419 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LKDESLSEAQRQEKRLQHAQKETEYL--------RLKRLRLGVEDFEALKVIGRGAFGEVRLVQK 112
            |.||..:...|:||.:      .|||        ::|::||..||||.||||||||||||.:|:.
Mouse    38 LYDECNNSPLRREKNI------LEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKL 96

  Fly   113 KDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGD 177
            |:...|:|||:|.|.:||::.:.|..|.||||||..|.:|:..::|:|||..||||:|::..|||
Mouse    97 KNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGD 161

  Fly   178 MMTLLMK-KDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGL 241
            ::|||.| :|.|.||..:||::|..:||||:|:|.::||||||||:|:|..||::|:|||.|..|
Mouse   162 LLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL 226

  Fly   242 KKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVF- 305
            .:.                  ||..|                    ::|   |||||||:||:.
Mouse   227 MED------------------GTVQS--------------------SVA---VGTPDYISPEILQ 250

  Fly   306 -LQTG---YGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEI-PISEEAK 365
             ::.|   |||.||||||||.|||||.|..||.:::..:||.|:||.:|...||.:: .:||.||
Mouse   251 AMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAK 315

  Fly   366 ETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEHIRERPAAIPVEVRSIDDTSNFDEFPDVSL 430
            :.|....|..:.||| |.|:||.|..|||.|:||::||...|....||.|..||||||...|...
Mouse   316 DLIRRLICSREHRLG-QNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLK 379

  Fly   431 EIPSAPIP-----QGGEIAKDWVFINYTY 454
            ...:.|.|     .|..:.    |:.:||
Mouse   380 NSETMPPPTHTAFSGHHLP----FVGFTY 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	9/36 (25%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	163/376 (43%)
Cdc42bpa	XP_017175608.1	STKc_MRCK_alpha	4..412	CDD:270773	175/419 (42%)
		SbcC	<442..>941	CDD:223496
		KELK	530..608	CDD:406277
		C1_MRCKalpha	1027..1086	CDD:410414
		PH_MRCK	1088..1222	CDD:269949
		CNH	1248..1512	CDD:395630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920