DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Cdc42bpb

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_006515826.1	Gene:	Cdc42bpb / 217866	MGIID:	2136459	Length:	1730	Species:	Mus musculus

Alignment Length:	448	Identity:	184/448 - (41%)
Similarity:	251/448 - (56%)	Gaps:	87/448 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KQRLAKLEAQL------KDESLS-----------------EAQRQEKR----LQHAQKETEYLRL 83
            |.||.|||..|      .|.:||                 .|.|::|.    |:.|:..|:.  :
Mouse     4 KVRLKKLEQLLLDGPWRNDSALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQL--V 66

  Fly    84 KRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEA 148
            |.::|..||||.:|||||||||||.:|:.|:|..:||||:|.|.:||::.:.|..|.||||||..
Mouse    67 KDMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG 131

  Fly   149 DHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMK-KDTLSEEGTQFYISETALAIDSIHKLGF 212
            |.||:..::|:|||...|||:|::..|||::|||.| :|.|.|:..:|||.|..|||||||:|.:
Mouse   132 DCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHY 196

  Fly   213 IHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKR 277
            :||||||||:|||..||::|:|||                                ||..|:...
Mouse   197 VHRDIKPDNVLLDVNGHIRLADFG--------------------------------SCLKMNDDG 229

  Fly   278 RAESWKRNRRALAYSTVGTPDYIAPEVF--LQTG---YGPACDWWSLGVIMYEMLMGYPPFCSDN 337
            ..:|      ::|   |||||||:||:.  ::.|   |||.||||||||.|||||.|..||.:::
Mouse   230 TVQS------SVA---VGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAES 285

  Fly   338 PQDTYRKVMNWRETLIFPPEI-PISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEH 401
            ..:||.|:||..|...||..: .:|||||:.|....|..:|||| |.|:||.|...||.|::||:
Mouse   286 LVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLG-QNGIEDFKKHAFFEGLNWEN 349

  Fly   402 IRERPAAIPVEVRSIDDTSNFDEFPDV--SLEIPSAPIPQGGEIAKDWV---FINYTY 454
            ||...|....:|.|..||||||...|:  ::||    :|.|.......:   ||.:|:
Mouse   350 IRNLEAPYIPDVSSPSDTSNFDVDDDMLRNIEI----LPPGSHTGFSGLHLPFIGFTF 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	16/65 (25%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	166/376 (44%)
Cdc42bpb	XP_006515826.1	STKc_MRCK_beta	3..411	CDD:270774	184/448 (41%)
		SbcC	429..>933	CDD:223496
		KELK	527..606	CDD:374120
		C1	1044..1093	CDD:237996
		PH_MRCK	1103..1237	CDD:269949
		CNH	1263..1529	CDD:366300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920