Protein Alignment trc and Rock1

DIOPT Version :10

• Sequence 1: NP_001262071.1
• Gene: trc / 40165
• FlyBaseID: FBgn0003744
• Length: 463
• Species: Drosophila melanogaster
• Sequence 2: NP_033097.1
• Gene: Rock1 / 19877
• MGIID: 107927
• Length: 1354
• Species: Mus musculus
• Alignment Length: 403
• Identity: 157/403 - (38%)
• Similarity: 233/403 - (57%)
• Gaps: 60/403 - (14%)

  Fly    64 AQRQEKRLQH---AQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLR 125
            |.|:.|.:.:   ..|:| ..:::.||:..||:|.:|||||||||||:||:.|.|..|||||:|.
Mouse    45 ALRKNKNIDNFLSRYKDT-INKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLS 108

  Fly   126 KADMLEKEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSE 190
            |.:|:::...|....|||::..|:..|||:::|:|||...||::||::||||::.|:...| :.|
Mouse   109 KFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD-VPE 172

  Fly   191 EGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQ 255
            :..:||.:|..||:|:||.:||||||:||||:|||..|||||:|||.|..:.|.
Mouse   173 KWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKE----------- 226

  Fly   256 AKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTG----YGPACDW 316
                      ..:.|.                    :.|||||||:|||....|    ||..|||
Mouse   227 ----------GMVRCD--------------------TAVGTPDYISPEVLKSQGGDGYYGRECDW 261

  Fly   317 WSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGS 381
            ||:||.:||||:|..||.:|:...||.|:||.:.:|.||.:..||:|||..|..|..:.:.|||
Mouse   262 WSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLG- 325

  Fly   382 QRGLEDLKSVPFFRGVD--WEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQ---GG 441
            :.|:|::|...||:...  ||.:|:..|.:..::.|..||||||:..:...:..:.|||:   |.
Mouse   326 RNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGN 390

  Fly   442 EIAKDWVFINYTY 454
            ::.    |:.:||
Mouse   391 QLP----FVGFTY 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	MobB_Trc-like	24..88	CDD:439274	6/26 (23%)
		STKc_NDR_like	91..455	CDD:270750	150/373 (40%)
Rock1	NP_033097.1	STKc_ROCK1	2..406	CDD:270772	157/403 (39%)
		Interaction with FHOD1. /evidence=ECO:0000250	368..727		9/36 (25%)
		SMC_prok_B	<412..1097	CDD:274008
		HR1_ROCK1	489..554	CDD:212029
		SHROOM3 binding. /evidence=ECO:0000269|PubMed:22493320	707..946
		ROCK_SBD	836..913	CDD:409019
		RHOA binding. /evidence=ECO:0000250	998..1010
		Auto-inhibitory. /evidence=ECO:0000250	1115..1354
		PH_ROCK	1119..1225	CDD:269948
		C1_ROCK1	1222..1290	CDD:410424
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1333..1354