DRSC/TRiP Functional Genomics Resources

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Protein Alignment trc and Prkce

DIOPT Version :10

Sequence 1:NP_001262071.1 Gene:trc / 40165 FlyBaseID:FBgn0003744 Length:463 Species:Drosophila melanogaster
Sequence 2:NP_035234.1 Gene:Prkce / 18754 MGIID:97599 Length:737 Species:Mus musculus


Alignment Length:403 Identity:127/403 - (31%)
Similarity:211/403 - (52%) Gaps:65/403 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 QRLAKLEAQLKDESLSEAQRQEK---------RLQHAQKETEYLRLKRLRLGVEDFEALKVIGRG 102
            |.|.:||..:: ::||...|.|:         :|....:..|....:..|||:::|..:||:|:|
Mouse   354 QELKELENNIR-KALSFDNRGEEHRASSATDGQLASPGENGEVRPGQAKRLGLDEFNFIKVLGKG 417

  Fly   103 AFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEA-DHQWVVKMYYSFQDPVNL 166
            :||:|.|.:.|....|||:|||:|..:|:.:.|.....|:.:|..| .|.::.::|..||....|
Mouse   418 SFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRL 482

  Fly   167 YLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLK 231
            :.:||::.|||:|..:.:.....|..::||.:|...|:..:|:.|.|:||:|.||:||||.||.|
Mouse   483 FFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCK 547

  Fly   232 LSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGT 296
            |:|||:|                  |.....|...:..|                        ||
Mouse   548 LADFGMC------------------KEGIMNGVTTTTFC------------------------GT 570

  Fly   297 PDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPIS 361
            |||||||:..:..|||:.|||:|||:||||:.|.|||.:||..|.:..:::  :.:::|  :.:|
Mouse   571 PDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILH--DDVLYP--VWLS 631

  Fly   362 EEAKETIINFCCE-ADRRLG---SQRGLEDLKSVPFFRGVDWEHIRERPAAIPVE--VRSIDDTS 420
            :||...:..|..: ..:|||   :|.|.:.:|..|||:.:||..:.::....|.:  :::..|.:
Mouse   632 KEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVN 696

  Fly   421 NFDEFPDVSLEIP 433
            |||:  |.:.|.|
Mouse   697 NFDQ--DFTREEP 707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trcNP_001262071.1 MobB_Trc-like 24..88 CDD:439274 10/49 (20%)
STKc_NDR_like 91..455 CDD:270750 114/350 (33%)
PrkceNP_035234.1 C2_PKC_epsilon 3..135 CDD:175981
C1_nPKC_epsilon-like_rpt1 161..224 CDD:410385
Interaction with actin 223..228
C1_nPKC_epsilon-like_rpt2 241..295 CDD:410388
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 310..356 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..398 4/27 (15%)
STKc_nPKC_epsilon 412..732 CDD:270743 113/344 (33%)
Blue background indicates that the domain is not in the aligned region.

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