DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trc and kin-4

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001255551.1	Gene:	kin-4 / 178068	WormBaseID:	WBGene00002192	Length:	1831	Species:	Caenorhabditis elegans

Alignment Length:	516	Identity:	151/516 - (29%)
Similarity:	229/516 - (44%)	Gaps:	138/516 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DGASIRFSDH-----TLDKATKAKVTLENYYSNLVT--QYGERKQRLAKL--EAQLK--DESLSE 63
            |||: ||..|     .||...|:|       .:|:|  .:.|..|||.:.  |||:|  .|||..
Worm   652 DGAT-RFLHHQIVEIALDCLGKSK-------DDLITCSYFCEMSQRLEETLNEAQMKTSPESLEY 708

  Fly    64 AQRQEKRL---------------------QHAQKETEYLRLKRL----------------RLGV- 90
            ..:..|:|                     .|..:|.|.:..::|                :||:
Worm   709 LSKLVKKLLMIVSRPARLLECLEFDPDEFYHLLEEAEGVVREQLGSGTARVPDLPQYIIGKLGLD 773

  Fly    91 -------------------------------------------EDFEALKVIGRGAFGEVRLVQK 112
                                                       :||:.::::..||:|.|.||:.
Worm   774 RDPLIDSTEHVDSSENTHATTSGTTSAKGAGSAWQETNRAPCEDDFDTIRLVSNGAYGAVYLVRH 838

  Fly   113 KDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGD 177
            ::|...:|:|.:.|..::.:.||..|.||||:|..||:.:||..|.||:....|.::||::.|||
Worm   839 RETRQRFALKKMNKQTLMLRNQVDQVFAERDILTMADNPFVVSFYGSFETRQYLCMLMEYVEGGD 903

  Fly   178 MMTLLMKKDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLC-TGL 241
            ...||....||..|..:.|::||.|||:.:|..|.:|||:||||||:.|.||:||:||||. .||
Worm   904 CAALLKSAGTLPVELVRLYVAETILAIEYLHSYGIVHRDLKPDNLLITAMGHIKLTDFGLSKIGL 968

  Fly   242 KKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFL 306
              .:||....:          |..|.:.......|:               ..|||:||||||.|
Worm   969 --MNRTTLVAE----------GYDAVVETQQFQDKQ---------------LCGTPEYIAPEVIL 1006

  Fly   307 QTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINF 371
            :.|||...|||:||:|:||.|:|..||..:.|:..:.||::  |.:.:|.|   .|.......:.
Worm  1007 RRGYGKPVDWWALGIILYEFLVGIVPFFGETPEALFSKVIS--EDVEYPEE---DEALPPEAADL 1066

  Fly   372 C---CEAD--RRLGSQRGLEDLKSVPFFRGVDWEHIRERPAAIPVEVRSIDDTSNFDEFPD 427
            |   .|.:  .|||:..|...|.:..||..:|:..:..:.|....::.:.:|||.||...|
Worm  1067 CRRLLEKNPAERLGTLNGAAQLMAHEFFILLDFTSLLRQKAEFVPQLDNEEDTSYFDTRTD 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	24/100 (24%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	120/343 (35%)
kin-4	NP_001255551.1	DUF1908	455..779	CDD:286070	31/134 (23%)
		STKc_MAST	818..1099	CDD:270760	112/312 (36%)
		S_TKc	819..1094	CDD:214567	109/306 (36%)
		PDZ_signaling	1434..1521	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920