DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and DMPK

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001275693.1	Gene:	DMPK / 1760	HGNCID:	2933	Length:	655	Species:	Homo sapiens

Alignment Length:	416	Identity:	161/416 - (38%)
Similarity:	230/416 - (55%)	Gaps:	65/416 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QEKRLQHAQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLE 131
            ||.....::.|...:|||.:||..:|||.|||||||||.||.:|:.|.||.|||||::.|.|||:
Human    71 QEPPASESRAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLK 135

  Fly   132 KEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMK-KDTLSEEGTQF 195
            :.:|:..|.||||||..|.:|:.:::::|||...|||:||:..|||::|||.| .:.:..|..:|
Human   136 RGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARF 200

  Fly   196 YISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSD 260
            |::|..:||||:|:||::||||||||:|||..||::|:|||.|..|    |.|
Human   201 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKL----RAD------------ 249

  Fly   261 FIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTG-------YGPACDWWS 318
              ||..||                       ..||||||::||:....|       |||.||||:
Human   250 --GTVRSL-----------------------VAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWA 289

  Fly   319 LGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFP-PEIPISEEAKETIINFCCEADRRLGSQ 382
            |||..|||..|..||.:|:..:||.|:::::|.|..| .:..:.|||::.|....|..:.||| :
Human   290 LGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLG-R 353

  Fly   383 RGLEDLKSVPFFRGVDWEHIRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPIPQGGEIAKD- 446
            .|..|.::.|||.|:||:.:|:.......:.....||.|||...|..    :|.:..|||...|
Human   354 GGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGL----TAMVSGGGETLSDI 414

  Fly   447 ---------WVFINYTYKRFEVRNLE 463
                     ..|:.|:|....:|:.|
Human   415 REGAPLGVHLPFVGYSYSCMALRDSE 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	5/17 (29%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	150/382 (39%)
DMPK	NP_001275693.1	STKc_DMPK_like	95..432	CDD:270748	150/382 (39%)
		S_TKc	97..365	CDD:214567	130/309 (42%)
		DMPK_coil	496..556	CDD:117396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020