DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and Stk38

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	NP_001344102.1	Gene:	Stk38 / 106504	MGIID:	2442572	Length:	465	Species:	Mus musculus

Alignment Length:	445	Identity:	313/445 - (70%)
Similarity:	377/445 - (84%)	Gaps:	11/445 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKETEYL 81
            |:||.::.|..||||||:||||:.|:.||:.|..|||..:::|.|.:.:::.:|..||:||||:|
Mouse    13 SNHTKERVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFL 77

  Fly    82 RLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLV 146
            ||||.|||:||||:|||||||||||||||||||||||||||:||||||||||||.|:|||||:||
Mouse    78 RLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILV 142

  Fly   147 EADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIHKLG 211
            |||..|||||:|||||.:||||||||||||||||||||||||:||.|||||:||.|||||||:||
Mouse   143 EADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLG 207

  Fly   212 FIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPMDSK 276
            ||||||||||||||::||:|||||||||||||:|||:|||:|:.:.||||       :...|:||
Mouse   208 FIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDF-------TFQNMNSK 265

  Fly   277 RRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDT 341
            |:||:||||||.||:||||||||||||||:||||...||||||||||||||:|||||||:.||:|
Mouse   266 RKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQET 330

  Fly   342 YRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEHIRERP 406
            |:|||||:|||.||||:|:||:||..|:.||||.:.|:|:. |:|::|:..||.|||||||||||
Mouse   331 YKKVMNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAP-GVEEIKNNLFFEGVDWEHIRERP 394

  Fly   407 AAIPVEVRSIDDTSNFDEFPDVSLEIPSAPI---PQGGEIAKDWVFINYTYKRFE 458
            |||.:|::||||||||||||:..:..|:...   |:.....||||||||||||||
Mouse   395 AAISIEIKSIDDTSNFDEFPESDILKPTVTTSSHPETDYKNKDWVFINYTYKRFE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	33/67 (49%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	270/366 (74%)
Stk38	NP_001344102.1	Interaction with S100B. /evidence=ECO:0000250	62..87		15/24 (63%)
Stk38	NP_001344102.1	STKc_NDR1	87..462	CDD:270777	275/371 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849249
Domainoid	1	1.000	476	1.000	Domainoid score	I432
eggNOG	1	0.900	-	-		E1_KOG0605
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56033
Inparanoid	1	1.050	659	1.000	Inparanoid score	I761
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216969at33208
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm42347
orthoMCL	1	0.900	-	-		OOG6_100850
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R870
SonicParanoid	1	1.000	-	-		X595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790