DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trc and cdc42bpa

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_031758436.1	Gene:	cdc42bpa / 100497067	XenbaseID:	XB-GENE-6037508	Length:	1829	Species:	Xenopus tropicalis

Alignment Length:	444	Identity:	178/444 - (40%)
Similarity:	247/444 - (55%)	Gaps:	87/444 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LKDESLSEAQRQEKRL-QHAQKETEY-LRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHV 118
            |.||..:...|::|.: .:.|....: |::|::||..||||.||||||||||||.:|:.|:...|
Frog    36 LYDECSASPLRRDKHINDYIQWAKPFALKVKQMRLHKEDFEILKVIGRGAFGEVAVVKLKNADKV 100

  Fly   119 YAMKVLRKADMLEKEQVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLM 183
            :|||:|.|.:||::.:.|..|.||||||..|.||:..::|:|||..||||:|::..|||::|||.
Frog   101 FAMKILNKWEMLKRAETACFREERDVLVNGDSQWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLS 165

  Fly   184 K-KDTLSEEGTQFYISETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRT 247
            | :|.|.|:.::||::|..|||||:|:|.::||||||||:|||..||::|:|||.|..|.:.
Frog   166 KFEDRLPEDMSRFYLAEMVLAIDSVHQLHYVHRDIKPDNILLDMNGHIRLADFGSCLKLMED--- 227

  Fly   248 DFYRDLSQAKPSDFIGTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVF--LQTG- 309
                           ||..|                    ::|   |||||||:||:.  ::.|
Frog   228 ---------------GTVQS--------------------SVA---VGTPDYISPEILQAMEDGK 254

  Fly   310 --YGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEI-PISEEAKETIINF 371
              |||.||||||||.|||||.|..||.:::..:||.|:||.:|...||.:: .:||.||:.|...
Frog   255 GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQLADVSENAKDLIRRL 319

  Fly   372 CCEADRRLGSQRGLEDLKSVPFFRGVDWEHIRERPAAIPVEVRSIDDTSNFDE------------ 424
            .|..:.||| |.|:||.|:.|||.|:||::||...|....||.|..||||||.
Frog   320 ICSREHRLG-QNGIEDFKNHPFFVGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNCTGAS 383

  Fly   425 ----------FPDVSLEIPSAPIPQG--------------GEIAKDWVFINYTY 454
                      .||:..|..:.|.|.|              |.......|:.:||
Frog   384 VPSHPYSIDLAPDLQAEGLTEPSPNGQHPVAETMPPPTHTGFSGHHLPFVGFTY 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	7/30 (23%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	168/407 (41%)
cdc42bpa	XP_031758436.1	PKc_like	4..445	CDD:419665	178/444 (40%)
		SbcC	<475..965	CDD:223496
		KELK	563..641	CDD:406277
		C1_MRCKalpha	1081..1140	CDD:410414
		PH_MRCK	1142..1276	CDD:269949
		CNH	1302..1566	CDD:395630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010