DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and stk38

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_031752645.1	Gene:	stk38 / 100379821	XenbaseID:	XB-GENE-5742605	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	448	Identity:	318/448 - (70%)
Similarity:	381/448 - (85%)	Gaps:	11/448 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IRFSDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQKET 78
            |..|:||.::.|..|:||||:||||:||:.||:.|..:||..:.:|.|.:.:::.:|..||:|||
Frog    42 ISMSNHTKERVTMTKMTLENFYSNLITQHEERELRQKRLEKAMDEEGLRDEEKRMRRSAHARKET 106

  Fly    79 EYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERD 143
            |:|||||.|||:||||:|||||||||||||||||||||||||||:|||.||||||||.|:|||||
Frog   107 EFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKTDMLEKEQVGHIRAERD 171

  Fly   144 VLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSIH 208
            :|||||..|||||:|||||.:||||||||||||||||||||||||:||.|||||:||.|||||||
Frog   172 ILVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIH 236

  Fly   209 KLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCSPM 273
            :||||||||||||||||::||:|||||||||||||:|||||||:|:.:.||||       :...|
Frog   237 QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTDFYRNLNHSLPSDF-------NFQNM 294

  Fly   274 DSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNP 338
            :|||:||:||||||.||:|||||||||||||||||||...||||||||||||||:|||||||:.|
Frog   295 NSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFLQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETP 359

  Fly   339 QDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEHIR 403
            |:||:|||||:||||||||:||||:||:.|:.||||.::|:|:. |:|::|:..||.||||||||
Frog   360 QETYKKVMNWKETLIFPPEVPISEKAKDLILRFCCEWEQRVGAP-GVEEIKTNHFFEGVDWEHIR 423

  Fly   404 ERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPI---PQGGEIAKDWVFINYTYKRFE 458
            |||||||:|::|||||||||||||..:..|...:   |:.....||||||||||||||
Frog   424 ERPAAIPIEIKSIDDTSNFDEFPDSDILKPMGAVSNHPESEFKNKDWVFINYTYKRFE 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	32/68 (47%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	275/366 (75%)
stk38	XP_031752645.1	STKc_NDR1	119..494	CDD:270777	280/371 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	481	1.000	Domainoid score	I412
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56033
Inparanoid	1	1.050	665	1.000	Inparanoid score	I756
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216969at33208
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm47455
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R870
SonicParanoid	1	1.000	-	-		X595
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190