DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trc and stk38b

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_017208958.1	Gene:	stk38b / 100332206	ZFINID:	ZDB-GENE-081031-2	Length:	469	Species:	Danio rerio

Alignment Length:	453	Identity:	313/453 - (69%)
Similarity:	384/453 - (84%)	Gaps:	14/453 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ASIRFSDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQEKRLQHAQK 76
            :|...|:||.::.|.|||||||:||||:||:.||:.|..|||..:.:|.|.:.:::.:|.|||:|
Zfish     8 SSSLMSNHTKERVTMAKVTLENFYSNLITQHEEREMRQQKLEKVMDEEGLPDEEKRVRRSQHARK 72

  Fly    77 ETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAE 141
            |||:|||||.|||::|||:|||||||||||||||||||||||||||:|||||||:||||||:|||
Zfish    73 ETEFLRLKRTRLGLDDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLQKEQVAHIRAE 137

  Fly   142 RDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDS 206
            ||:||:||..|||||:|||||.:||||:|||||||||||||||||||:||.||||::||.||||.
Zfish   138 RDILVQADSLWVVKMFYSFQDKLNLYLLMEFLPGGDMMTLLMKKDTLTEEETQFYVAETVLAIDF 202

  Fly   207 IHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFIGTCASLSCS 271
            ||:||||||||||||||||::||:|||||||||||||:|||:|||:|:.::.:|       |:..
Zfish   203 IHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSQSND-------LTFQ 260

  Fly   272 PMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSD 336
            .|:|||:||:||||||.||:||||||||||||||:||||...||||||||||||||:|||||||:
Zfish   261 HMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSE 325

  Fly   337 NPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLEDLKSVPFFRGVDWEH 401
            .||:||:|||.|:|||:||||:||||.|||.|:.||||||.|:|: .|::|:|...||.|||::|
Zfish   326 TPQETYKKVMGWKETLVFPPEVPISERAKELILRFCCEADHRIGA-GGVDDIKRNAFFEGVDYDH 389

  Fly   402 IRERPAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPI------PQGGEIAKDWVFINYTYKRFE 458
            ||||||||.:|::|||||||||||||..:..|::|:      |:.....||||||||||||||
Zfish   390 IRERPAAITIEIKSIDDTSNFDEFPDSDILQPTSPVVVSNHHPESDYKNKDWVFINYTYKRFE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	36/68 (53%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	266/369 (72%)
stk38b	XP_017208958.1	PKc_like	87..465	CDD:304357	271/374 (72%)
stk38b	XP_017208958.1	S_TKc	89..382	CDD:214567	225/300 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594832
Domainoid	1	1.000	482	1.000	Domainoid score	I392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	667	1.000	Inparanoid score	I725
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216969at33208
OrthoFinder	1	1.000	-	-		FOG0000273
OrthoInspector	1	1.000	-	-		otm25356
orthoMCL	1	0.900	-	-		OOG6_100850
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900