DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trc and cita

DIOPT Version :9

Sequence 1:	NP_001262071.1	Gene:	trc / 40165	FlyBaseID:	FBgn0003744	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_021332398.1	Gene:	cita / 100329792	ZFINID:	ZDB-GENE-130530-981	Length:	2358	Species:	Danio rerio

Alignment Length:	469	Identity:	139/469 - (29%)
Similarity:	215/469 - (45%)	Gaps:	105/469 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRTQDADGASIRFSDHTLDKATKAKVTLENYYSNLVTQYGERKQRLAKLEAQLKDESLSEAQRQE 68
            ||....|...:.|.:.:..:..|.|     :.:|.|.:|               .|.::|.|
Zfish    48 SREGLIDALLLLFQECSTPELMKIK-----HVANFVNKY---------------SEVVAEVQ--- 89

  Fly    69 KRLQHAQKETEYLRLKRLRLGVEDFEALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKE 133
                            .|..|.:|||...::|||.|.||::|:::.||.|||||::.|..:....
Zfish    90 ----------------ELLPGKKDFEVRGIVGRGQFSEVQVVKERATGDVYAMKIMDKNSLRSHH 138

  Fly   134 QVAHVRAERDVLVEADHQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMK-KDTLSEEGTQFYI 197
            .||....|:.:|......|:.::.::|||..::.|:||:|||||:|.|:.: :|...|...|||:
Zfish   139 NVAFFEEEKSILALNSSPWIPQLQHAFQDQDHVCLVMEYLPGGDLMALMNRYEDQFDESMAQFYL 203

  Fly   198 SETALAIDSIHKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKPSDFI 262
            :|...|:.::|::|::||||:|:|:|:|..||:||:|||....|..:      |.::.:|
Zfish   204 AELIQAVHTLHQMGYVHRDIRPENVLIDRTGHIKLADFGWAARLTAN------RTVTSSK----- 257

  Fly   263 GTCASLSCSPMDSKRRAESWKRNRRALAYSTVGTPDYIAPEVFLQTGYGPAC------DWWSLGV 321
                                         ..||.||::|||:......|.||      |||||||
Zfish   258 -----------------------------LPVGPPDFLAPEILSAFSGGSACNHGPESDWWSLGV 293

  Fly   322 IMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISEEAKETIINFCCEADRRLGSQRGLE 386
            |.|||:....||.......|...::|::..|.||.|...|....:.:.:..|.:..||    |.|
Zfish   294 IAYEMIYMKSPFTDGTSTKTINNIINFQRFLKFPEEPKASAAFMDLLQSLLCGSVERL----GYE 354

  Fly   387 DLKSVPFFRGVDWEHIRER-PAAIPVEVRSIDDTSNFDEFPDVSLEIPSAPI--------PQGGE 442
            .|:|.|||..|||.::|.. |..:| .:||.||..|| |.|    |.|..|.        |:.|.
Zfish   355 GLRSHPFFSSVDWTNLRHALPPFVP-SLRSEDDACNF-EAP----ERPPRPATAAAQPEHPRSGF 413

  Fly   443 IAKDWVFINYTYKR 456
            ..:|..|:.:.:.|
Zfish   414 HGRDLPFVGWCFSR 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trc	NP_001262071.1	OmpH	16..>85	CDD:214922	9/68 (13%)
trc	NP_001262071.1	STKc_NDR_like	91..455	CDD:270750	124/379 (33%)
cita	XP_021332398.1	PKc_like	96..426	CDD:328722	124/379 (33%)
		SMC_N	476..1287	CDD:330553
		C1	1430..1478	CDD:237996
		PH	1511..1630	CDD:214574
		CNH	1674..1970	CDD:321933
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920