DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Deaf1 and deaf1

DIOPT Version :9

Sequence 1:	NP_001262069.1	Gene:	Deaf1 / 40164	FlyBaseID:	FBgn0013799	Length:	576	Species:	Drosophila melanogaster
Sequence 2:	XP_005174312.1	Gene:	deaf1 / 563776	ZFINID:	ZDB-GENE-081022-163	Length:	532	Species:	Danio rerio

Alignment Length:	559	Identity:	155/559 - (27%)
Similarity:	231/559 - (41%)	Gaps:	157/559 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GGGGVVSVPVSLP----------------IGSMITGT----TFNVITPDQLPPHFKPMLCVDNNG 121
            |..|.:.:..|||                :|.:.:..    |..|.|...:|.|
Zfish    44 GEAGTIDITESLPNPDDAETAFAEVTAVTVGDVQSSDDSVFTSAVATATSIPEH----------- 97

  Fly   122 YLSG-STVSMGNDLKT-----IVIQQQQTQPGGGGGGANNAGTNTTATNTIGLNHDGSGSNNSHD 180
            .|:| :|:.:||.|.|     ||:...         |:....|:..||.|    ....|....:.
Zfish    98 VLTGRATLQIGNTLSTQKATLIVVHTD---------GSIVDATSLKATGT----PMTPGPQTPNT 149

  Fly   181 SLATLEHAAGGASGVGGGGGGTGGGSSGWSENPSTQHNEVFQIRCKTTCAELYRSKLGSGGRGRC 245
            .||:                |.....|.::.:||...||: .:||:.|...||:::|||||:|||
Zfish   150 PLAS----------------GHDKDVSKYNWDPSVYDNEL-PVRCRNTSGLLYKNRLGSGGKGRC 197

  Fly   246 VKYKDKWHTPSEFEHVCGRGSSKDWKRSIKYGGKSLQSLIDEGTLTPHATNCSCTVCCDD----- 305
            :|:.:.|:||:|||.:.||.|||||||||:|.|:.||.||.|..|.|||.:|:|..||||
Zfish   198 IKHNNSWYTPTEFEGMSGRASSKDWKRSIRYAGRPLQCLIQERILNPHAASCTCAACCDDLSTVS 262

  Fly   306 ----------EAGESASGPVRLFTPYKRRKRNQTDLDMESGPKRKRNTHHSNN---------NNS 351
                      :...|.:||||||.||||||:   |.:..:.|..|:......|         ..|
Zfish   263 DTCTKEGSYGQESLSMTGPVRLFVPYKRRKK---DNERAASPDNKKEIQSPKNITLAPGATFTVS 324

  Fly   352 NTNNNNTSGSGANNCVDVTAAVAAATASVVDE---------NNMFLS----------EENITSKD 397
            .:...:|||:     :....:.:..|||::.:         |...|:          :..:.||.
Zfish   325 PSGQISTSGT-----LSFDRSASGETASIISDSPAAPDVYTNTTVLTTLPALAVVPQQAVVQSKP 384

  Fly   398 EPWAALNDSLDTSTE--LVDQSQMGNTYERETFVVNINDGSSIAVLDTSQSMKNIEHVYCTMVKA 460
            .|...|.:.|:|..:  .:...:|.||.        :::...:.||.......:....:.|:...
Zfish   385 PPAGTLLNGLETGEQRTWLYLEEMANTL--------LSNVQQLKVLIAQAKQASQSGAHATISPD 441

  Fly   461 TNDFKRMLNDMKQSFERRIEVLQKERDAAVSAMRVQVHADIDDPNISGSLHGNEIISAKKCANCN 525
            .|...|     |:||:.:.. |.:|.:..::                      |||....|.||.
Zfish   442 KNSSGR-----KESFQSQFS-LTEEPEGKIT----------------------EIIIKHTCVNCG 478

  Fly   526 REALAECSLCRKTPYCSEFCQRKDWNAHQVECTRNPQTT 564
            |||..||:.|.|..|||.|||||||..||:.|.: |.|:
Zfish   479 REASCECTGCHKVHYCSGFCQRKDWKEHQLNCCQ-PNTS 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Deaf1	NP_001262069.1	SAND	219..291	CDD:128554	39/71 (55%)
Deaf1	NP_001262069.1	zf-MYND	521..557	CDD:280009	22/35 (63%)
deaf1	XP_005174312.1	SAND	168..242	CDD:279658	40/74 (54%)
deaf1	XP_005174312.1	zf-MYND	474..510	CDD:280009	22/35 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594704
Domainoid	1	1.000	94	1.000	Domainoid score	I7453
eggNOG	1	0.900	-	-		E1_KOG4333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3913
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D295114at33208
OrthoFinder	1	1.000	-	-		FOG0007969
OrthoInspector	1	1.000	-	-		oto39246
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5158
SonicParanoid	1	1.000	-	-		X5913
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890