Protein Alignment Deaf1 and GMEB2

DIOPT Version :10

• Sequence 1: NP_524169.1
• Gene: Deaf1 / 40164
• FlyBaseID: FBgn0013799
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_036516.1
• Gene: GMEB2 / 26205
• HGNCID: 4371
• Length: 530
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 76/375 - (20%)
• Similarity: 133/375 - (35%)
• Gaps: 92/375 - (24%)

  Fly   144 TQPGGGGGGANNAGTNTTATNTIGLNHDGSGSNNSHDSLATLEHAAGGASGVGGGGGGTGGGSSG 208
            |.|.....|:...|..|....|   |....|.:.:.|::.| |:||..|:.
Human    17 TTPDTAVDGSGVEGVKTVLVTT---NLAPHGGDLTEDNMET-ENAAAAAAA-------------- 63

  Fly   209 WSENPSTQHNE-----------------VFQIRCKTTCAEL-YRSKLGSGGRGRCVKYKDKWHTP 255
             :...|:|..|                 |:.|.|..:.|.| :|..:..|...:||:|.:...:|
Human    64 -AFTASSQLKEAVLVKMAEEGENLEAEIVYPITCGDSRANLIWRKFVCPGINVKCVQYDEHVISP 127

  Fly   256 SEFEHVCGRGSSKDWKRSIKYGGKSLQSLIDEGTLTPHATNCSCTVCCDDEAGESASGPVRLFTP 320
            .||.|:.|:.:.|||||:|:..|..|:.::|.|.|..:..:..|:..|.....:.:...|.|.:|
Human   128 KEFVHLAGKSTLKDWKRAIRMNGIMLRKIMDSGELDFYQHDKVCSNTCRSTKIDLSGARVSLSSP 192

  Fly   321 YKRRKRNQTDLDMESGPKRKRNTHHSNNNNSNTNNNNTSGSGANNCVDVTAAVAAATASVVDENN 385
            ........|....:                       .:||.|...::........||::.|:..
Human   193 TSAEYIPLTPAAAD-----------------------VNGSPATITIETCEDPGDWTAAIGDDTF 234

  Fly   386 MFLSEENITSKDEPWAALNDS--------------LDTSTELVDQSQMGNTYERETFVVNINDGS 436
            .|            |..|.|:              ::|...|..:.|......|:..::| |...
Human   235 TF------------WRGLKDAGLLDEVIQEFHQELVETMRGLQQRVQDPPLQLRDAVLLN-NIVQ 286

  Fly   437 SIAVLDTSQSMKNIEHVYCTMVKATNDFKRMLNDMKQSFE---RRIEVLQ 483
            :..:||..:  |.:....|.|.::...:.|.|..::|..:   ||.:.|:
Human   287 NFGMLDLVK--KVLASHKCQMDRSREQYARDLAALEQQCDEHRRRAKELK 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Deaf1	NP_524169.1	SAND	219..291	CDD:128554	26/89 (29%)
		zf-MYND	521..557	CDD:460312
GMEB2	NP_036516.1	SAND	90..163	CDD:128554	25/72 (35%)