DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyc and ARNT2

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_055677.3	Gene:	ARNT2 / 9915	HGNCID:	16876	Length:	717	Species:	Homo sapiens

Alignment Length:	408	Identity:	167/408 - (40%)
Similarity:	249/408 - (61%)	Gaps:	36/408 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLR 81
            ::|:|.....|..:| :||||||:|||:||..||.|||.|:|.|.|:.||.||||:|||||.|::
Human    51 DFDDEDGEGPSKFSR-ENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK 114

  Fly    82 GIRGSGSLHPFNGSD--YRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQ 144
            .:||:|:    ..:|  |:||||::||||.:||:|::||||||..:.||::||||||:.|||..|
Human   115 SMRGTGN----KSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQ 175

  Fly   145 ADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSFFC 209
            ::..|.:.::.:||.|:.|::|||.:.|.....|::|.||. .||.:..||..|:|.|:||||.|
Human   176 SEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTG-TVKKEGQQSSMRMCMGSRRSFIC 239

  Fly   210 RMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTG--------HKYRVIQCTGYLKSWTP----I 262
            ||:...|       ..|....:|.:|.|| |...|        .:|.|:.||||:|:|.|    |
Human   240 RMRCGNA-------PLDHLPLNRITTMRK-RFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTI 296

  Fly   263 KDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQR 327
            .:||.|.....:    .|||||||:  .|.:|  |..:|.:.......|:|||:.:|...|:|.|
Human   297 PEEDADVGQGSK----YCLVAIGRL--QVTSS--PVCMDMNGMSVPTEFLSRHNSDGIITFVDPR 353

  Fly   328 ATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWR 392
            ...|||:.||::||....|:.|.||.:.|.||.:.|:::..:|.:.:||||.|:..::.:::...
Human   354 CISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSF 418

  Fly   393 AFKNPWTSEIDYIIAKNS 410
            .|:||::.||:|||..|:
Human   419 TFQNPYSDEIEYIICTNT 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	33/52 (63%)
		PAS	111..212	CDD:279347	47/100 (47%)
		PAS	111..173	CDD:214512	29/61 (48%)
		PAS_11	311..411	CDD:291273	38/100 (38%)
		PAS	311..406	CDD:238075	35/94 (37%)
ARNT2	NP_055677.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..74		10/23 (43%)
		bHLH-PAS_ARNT	62..124	CDD:381517	36/66 (55%)
		PAS	137..243	CDD:395786	51/106 (48%)
		PAS_11	336..436	CDD:405306	37/99 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..717
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820