Protein Alignment cyc and CLOCK

DIOPT Version :9

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: NP_001254772.1
• Gene: CLOCK / 9575
• HGNCID: 2082
• Length: 846
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 129/429 - (30%)
• Similarity: 197/429 - (45%)
• Gaps: 84/429 - (19%)

  Fly     7 CENMEEIED-----------ENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMC 60
            |..|..|.|           |..|::|:.|.|     :|.|  ||:|||:.|..|.||.||:|
Human     7 CSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVS-----RNKS--EKKRRDQFNVLIKELGSMLP-- 62

  Fly    61 FAMQRKLDKLTVLRMAVQHLR---GIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVV 122
             ...||:||.|||:.::..||   .|.......... .|::|:|||::|...::|:|.:||...:
Human    63 -GNARKMDKSTVLQKSIDFLRKHKEITAQSDASEIR-QDWKPTFLSNEEFTQLMLEALDGFFLAI 125

  Fly   123 GCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLP 187
            ..| |.|:|||:||:|:|....:||:.||.|:.:...:..:|.:.||:       .|:::.::.|
Human   126 MTD-GSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILST-------HLLESDSLTP 182

  Fly   188 VKTDVPQSLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQC 252
            ........|         .|.|.| ||           .|......||           |..::.
Human   183 EYLKSKNQL---------EFCCHM-LR-----------GTIDPKEPST-----------YEYVKF 215

  Fly   253 TGYLKSWTPIKDEDQDA-DSDEQTTNLS------CLVAIGRI--PPNVRN-STVPASLDNHPNIR 307
            .|..||...:.....:. :...|.|:..      |.||..|:  |..::. .||     ..||..
Human   216 IGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTV-----EEPNEE 275

  Fly   308 HVLFISRHSGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTT 372
               |.||||.|.||||:|.||..:||:||.|:||||.|:|:|.:|:..|.:.|:.:||. .|..:
Human   276 ---FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQY-GKGKS 336

  Fly   373 QVYRFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411
            ..|||..|...:|.||:.:....:.|.|..::|:..::|
Human   337 CYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTV 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	23/55 (42%)
		PAS	111..212	CDD:279347	27/100 (27%)
		PAS	111..173	CDD:214512	22/61 (36%)
		PAS_11	311..411	CDD:291273	41/99 (41%)
		PAS	311..406	CDD:238075	40/94 (43%)
CLOCK	NP_001254772.1	HLH	32..86	CDD:238036	26/63 (41%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O08785	32..47		7/21 (33%)
		PAS	109..>175	CDD:307226	23/73 (32%)
		PAS_3	274..377	CDD:330807	42/106 (40%)
		Interaction with NR3C1. /evidence=ECO:0000250|UniProtKB:O08785	371..845		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..411
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..495
		Interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:O08785	450..570
		Med15	<496..>686	CDD:312941
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..654
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..783
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	811..846

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910