Protein Alignment cyc and NCOA3

DIOPT Version :9

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: NP_858045.1
• Gene: NCOA3 / 8202
• HGNCID: 7670
• Length: 1424
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 98/383 - (25%)
• Similarity: 170/383 - (44%)
• Gaps: 77/383 - (20%)

  Fly    39 EKRRRDKMNTYINELSSMIPMCFA----MQRKLDKLTVLRMAVQHLRGIRGSGSLHPFNGSDYRP 99
            |||||::.:.||.||:.:|....:    ...|.||..:|:..|:.:|.|:..|.... |..|.:.
Human    34 EKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQK 97

  Fly   100 SFLSD--------QELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVL 156
            :.:|.        ..|..::|||.:||||||..| |.|::||::|:..|...|.||:..|.:::|
Human    98 ADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRD-GNIVFVSENVTQYLQYKQEDLVNTSVYNIL 161

  Fly   157 HPKDIGKVKEQLSSLEQCPRERLIDAKTMLPV----KTDVPQSLCRLCPGARRSFFCRMKLRTAS 217
            |.:|      :...|:..|:      .|:..|    :|...:|         .:|.|||.::|.
Human   162 HEED------RKDFLKNLPK------STVNGVSWTNETQRQKS---------HTFNCRMLMKTP- 204

  Fly   218 NNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKDEDQDADSDEQTTNLSCLV 282
             :.|.|:.:.|...|            .:|..:||.. |.....:.:|.:|..        ||::
Human   205 -HDILEDINASPEMR------------QRYETMQCFA-LSQPRAMMEEGEDLQ--------SCMI 247

  Fly   283 AIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQ---RATLVIGFLPQEILGTSF 344
            .:.|     |.:|...:..::|.    .||:||...||.:.||.   |:::..||  ::|:....
Human   248 CVAR-----RITTGERTFPSNPE----SFITRHDLSGKVVNIDTNSLRSSMRPGF--EDIIRRCI 301

  Fly   345 YEYFH-NEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSE 401
            ..:|. |:..:...:.|.....:.....|.||||...|.:.:..|::.:.|:||.|::
Human   302 QRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTND 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	16/48 (33%)
		PAS	111..212	CDD:279347	32/104 (31%)
		PAS	111..173	CDD:214512	24/61 (39%)
		PAS_11	311..411	CDD:291273	26/95 (27%)
		PAS	311..406	CDD:238075	26/95 (27%)
NCOA3	NP_858045.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		3/3 (100%)
		HLH	34..88	CDD:197674	18/53 (34%)
		PAS	116..173	CDD:214512	24/63 (38%)
		PAS	117..215	CDD:279347	36/121 (30%)
		PAS_11	265..375	CDD:291273	26/101 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	408..493
		NCOA_u2	459..572	CDD:293270
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..520
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..674
		SRC-1	620..704	CDD:285981
		LXXLL motif 1	685..689
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	709..730
		DUF4927	723..810	CDD:292896
		LXXLL motif 2	738..742
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	755..798
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	911..945
		Interaction with CREBBP. /evidence=ECO:0000269|PubMed:9346901	1023..1093
		Nuc_rec_co-act	1045..1092	CDD:285967
		LXXLL motif 3	1057..1061
		Acetyltransferase	1097..1304
		polyglutamine repeats	1248..1276
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1273..1321
		DUF1518	1291..1348	CDD:284808

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810