DRSC/TRiP Functional Genomics Resources

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Protein Alignment cyc and SIM2

DIOPT Version :10

Sequence 1:NP_524168.2 Gene:cyc / 40162 FlyBaseID:FBgn0023094 Length:413 Species:Drosophila melanogaster
Sequence 2:NP_005060.1 Gene:SIM2 / 6493 HGNCID:10883 Length:667 Species:Homo sapiens


Alignment Length:384 Identity:105/384 - (27%)
Similarity:175/384 - (45%) Gaps:58/384 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 KQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHL--RGIRGSGSLHPFNG 94
            |:......|.||:|.|....||:.::|:..|:..:|||.:::|:...:|  |.:...| |....|
Human     2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEG-LGDAWG 65

  Fly    95 SDYRPSFLSD--QELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLH 157
            ...|...|..  :||...:||..:||:|||..| |:|:|:|::.|..|..:|.:|.|.|.::.:|
Human    66 QPSRAGPLDGVAKELGSHLLQTLDGFVFVVASD-GKIMYISETASVHLGLSQVELTGNSIYEYIH 129

  Fly   158 PKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSFFCRMKLRTASNNQIK 222
            |.|..::...|::.:......|.:.:                   ..||||.|||...|      
Human   130 PSDHDEMTAVLTAHQPLHHHLLQEYE-------------------IERSFFLRMKCVLA------ 169

  Fly   223 EESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKDEDQDADSDEQTTNLSCLVAIGRI 287
                         ||.:.||.. .|:||.|:||||    |:....|....:....:..|||:|: 
Human   170 -------------KRNAGLTCS-GYKVIHCSGYLK----IRQYMLDMSLYDSCYQIVGLVAVGQ- 215

  Fly   288 PPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNED 352
                   ::|.|......:...:|:.|.|.:.|.:|:|.|.|.|.|:.||:::..:.|.:.|..|
Human   216 -------SLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCD 273

  Fly   353 IAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411
            :..|..:|.::: |..:|||:.||...|...::.:||......|..:|....|::.|.|
Human   274 VFHLRYAHHLLL-VKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYV 331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cycNP_524168.2 bHLH_SF 31..92 CDD:469605 18/61 (30%)
PAS 111..173 CDD:214512 22/61 (36%)
PAS_11 311..411 CDD:464214 30/99 (30%)
SIM2NP_005060.1 bHLH_SF 1..74 CDD:469605 20/72 (28%)
PAS 79..140 CDD:214512 23/61 (38%)
PAS_11 91..194 CDD:464214 41/146 (28%)
PAS_3 243..329 CDD:430001 25/86 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..389
SIM_C 358..660 CDD:461963
Nuclear localization signal. /evidence=ECO:0000269|PubMed:14697214 367..386
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..428
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..520
Blue background indicates that the domain is not in the aligned region.

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