DRSC/TRiP Functional Genomics Resources

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Protein Alignment cyc and SIM1

DIOPT Version :10

Sequence 1:NP_524168.2 Gene:cyc / 40162 FlyBaseID:FBgn0023094 Length:413 Species:Drosophila melanogaster
Sequence 2:NP_005059.2 Gene:SIM1 / 6492 HGNCID:10882 Length:766 Species:Homo sapiens


Alignment Length:388 Identity:108/388 - (27%)
Similarity:179/388 - (46%) Gaps:66/388 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 KQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLRGIR-----GSGSLHP 91
            |:......:.||:|.|:...||:.::|:..|:..:|||.:::|:...:|: :|     |.|... 
Human     2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLK-MRVVFPEGLGEAW- 64

  Fly    92 FNGSDYRPSFLSD--QELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSWFD 154
              |...|.|.|.:  :||...:||..:||:|||..| |:|:|:|::.|..|..:|.:|.|.|.::
Human    65 --GHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIYE 126

  Fly   155 VLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSFFCRMKLRTASNN 219
            .:||.|..::...|::.:              |..:...|..     ...||||.|||...|   
Human   127 YIHPADHDEMTAVLTAHQ--------------PYHSHFVQEY-----EIERSFFLRMKCVLA--- 169

  Fly   220 QIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIKDEDQDADSDEQTTNLSCLVAI 284
                            ||.:.||.| .|:||.|:||||    |:....|....:.......|||:
Human   170 ----------------KRNAGLTCG-GYKVIHCSGYLK----IRQYSLDMSPFDGCYQNVGLVAV 213

  Fly   285 GR-IPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLPQEILGTSFYEYF 348
            |. :||     :....:..|.|    :|:.|.|.:.|.:|:|.|...:.|:.||:::..:.|.:.
Human   214 GHSLPP-----SAVTEIKLHSN----MFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHV 269

  Fly   349 HNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411
            |..|...|..:|.::: |..:|||:.|||..|...::.:||......|..:|....|::.|.|
Human   270 HGCDTFHLRCAHHLLL-VKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYV 331

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cycNP_524168.2 bHLH_SF 31..92 CDD:469605 17/64 (27%)
PAS 111..173 CDD:214512 22/61 (36%)
PAS_11 311..411 CDD:464214 29/99 (29%)
SIM1NP_005059.2 bHLH-PAS_SIM1 1..71 CDD:381581 19/72 (26%)
PAS 88..>158 CDD:238075 22/89 (25%)
PAS_3 243..329 CDD:430001 24/86 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 353..431
SIM_C 359..669 CDD:461963
Nuclear localization signal. /evidence=ECO:0000250 368..387
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 528..563
Blue background indicates that the domain is not in the aligned region.

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