DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyc and arnt2

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_009301213.1	Gene:	arnt2 / 64277	ZFINID:	ZDB-GENE-001207-3	Length:	738	Species:	Danio rerio

Alignment Length:	420	Identity:	173/420 - (41%)
Similarity:	261/420 - (62%)	Gaps:	40/420 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EIEDEN---------YDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKL 67
            :.:||:         ||:::.....:...::||||||:|||:||..||.|||.|:|.|.|:.||.
Zfish    51 DFDDEDGEGPSKFSRYDDDQIPGDKERYARENHSEIERRRRNKMTQYITELSDMVPTCSALARKP 115

  Fly    68 DKLTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYV 132
            ||||:|||||.|::.:||:|:... :|: |:||||::||||.:||:|::||||||..:.||::||
Zfish   116 DKLTILRMAVSHMKSMRGTGNTST-DGA-YKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYV 178

  Fly   133 SDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLC 197
            ||||:.|||..|::..|.:.|:.:||.|:.|::||||:.|.....|::|.||. .||.:..||..
Zfish   179 SDSVTPVLNHPQSEWFGSTLFEQVHPDDVDKLREQLSTSENSMTGRILDLKTG-TVKKEGQQSSM 242

  Fly   198 RLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTG--------HKYRVIQCTG 254
            |:|.|:||||.|||:..:|..:.|       |.:|.|:.|| |...|        .:|.|:.|||
Zfish   243 RMCMGSRRSFICRMRCGSAPLDHI-------SLNRLSSMRK-RYRNGLGPSKEGEAQYSVVHCTG 299

  Fly   255 YLKSWTP----IKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRH 315
            |:|:|.|    |.|||.:|..    |:..|||||||:  .|.:|  |.|:|.:.......|:|||
Zfish   300 YIKAWPPAGMTIPDEDTEAGQ----TSKYCLVAIGRL--QVTSS--PVSMDMNGLSVPTEFLSRH 356

  Fly   316 SGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCK 380
            :.:|...|:|.|...|||:.||::||....|:.|.||.:.|.||.:.|:::..:|.:.:||||.|
Zfish   357 NSDGIITFVDPRCINVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRMK 421

  Fly   381 DNSYIQLQSEWRAFKNPWTSEIDYIIAKNS 410
            :..::.:::....|:||::.||:|||..|:
Zfish   422 NREWMLIRTSSFTFQNPYSDEIEYIICTNT 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	32/52 (62%)
		PAS	111..212	CDD:279347	49/100 (49%)
		PAS	111..173	CDD:214512	31/61 (51%)
		PAS_11	311..411	CDD:291273	38/100 (38%)
		PAS	311..406	CDD:238075	35/94 (37%)
arnt2	XP_009301213.1	HLH	80..132	CDD:278439	32/51 (63%)
		PAS	152..258	CDD:279347	53/106 (50%)
		PAS	155..219	CDD:214512	31/63 (49%)
		PAS_11	351..451	CDD:291273	37/99 (37%)
		PAS	351..447	CDD:238075	35/95 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920