DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cyc and Clock

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001376183.1	Gene:	Clock / 60447	RGDID:	620271	Length:	864	Species:	Rattus norvegicus

Alignment Length:	429	Identity:	127/429 - (29%)
Similarity:	198/429 - (46%)	Gaps:	84/429 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CENMEEIED-----------ENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMC 60
            |..|..|.|           |..|::|:.|.|     :|.|  ||:|||:.|..|.||.||:|
  Rat     7 CSKMSSIVDRDDSSIFDGLVEEDDKDKAKRVS-----RNKS--EKKRRDQFNVLIKELGSMLP-- 62

  Fly    61 FAMQRKLDKLTVLRMAVQHLR---GIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVV 122
             ...||:||.|||:.::..||   .|.......... .|::|:|||::|...::|:|.:||...:
  Rat    63 -GNARKMDKSTVLQKSIDFLRKHKEITAQSDASEIR-QDWKPTFLSNEEFTQLMLEALDGFFLAI 125

  Fly   123 GCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLP 187
            ..| |.::|||::|:|:|....:||:.||.|:.:...:..:|.:.||:       .|:::.::.|
  Rat   126 MTD-GSVVYVSETVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILST-------HLLESDSLTP 182

  Fly   188 VKTDVPQSLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQC 252
            ........|         .|.|.| ||           .|......||           |..::.
  Rat   183 EDLKSKNQL---------EFCCHM-LR-----------GTIDPKEPST-----------YEYVRF 215

  Fly   253 TGYLKSWTPIKDEDQDA-DSDEQTTNLS------CLVAIGRI--PPNVRN-STVPASLDNHPNIR 307
            .|..||...:.....:. :...|.|:..      |.||..|:  |..::. .||     ..||..
  Rat   216 IGNFKSLNSVSTSTHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIKEMCTV-----EEPNEE 275

  Fly   308 HVLFISRHSGEGKFLFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTT 372
               |.||||.|.||||:|.||..:||:||.|:||||.|:|:|.:|:.:|.:.|:.:||. .|..:
  Rat   276 ---FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLESLAKCHEHLMQY-GKGKS 336

  Fly   373 QVYRFRCKDNSYIQLQSEWRAFKNPWTSEIDYIIAKNSV 411
            ..|||..|...:|.||:.:....:.|.|..::|:..::|
  Rat   337 CYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTV 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	23/55 (42%)
		PAS	111..212	CDD:279347	25/100 (25%)
		PAS	111..173	CDD:214512	20/61 (33%)
		PAS_11	311..411	CDD:291273	41/99 (41%)
		PAS	311..406	CDD:238075	40/94 (43%)
Clock	NP_001376183.1	bHLH-PAS_CLOCK	29..89	CDD:381577	28/69 (41%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O08785	32..47		7/21 (33%)
		PAS	109..202	CDD:395786	29/121 (24%)
		PAS_11	274..377	CDD:405306	42/106 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..497
		Interaction with SIRT1. /evidence=ECO:0000250\|UniProtKB:O08785	450..570
		Implicated in the circadian rhythmicity. /evidence=ECO:0000250	514..564
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	824..864
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910