DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyc and arntl2

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_571653.2	Gene:	arntl2 / 58099	ZFINID:	ZDB-GENE-000509-2	Length:	631	Species:	Danio rerio

Alignment Length:	415	Identity:	199/415 - (47%)
Similarity:	294/415 - (70%)	Gaps:	29/415 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ENMEEIEDENYD---EEKSARTSDENR------KQNHSEIEKRRRDKMNTYINELSSMIPMCFAM 63
            :|:|.....|.|   |:.:.|:.|:..      ::.||:||||||||||..|:||::|||.|..|
Zfish    58 DNLEMKSASNLDEDMEDDAGRSEDDQHLKIKCIREPHSQIEKRRRDKMNNLIDELAAMIPTCNPM 122

  Fly    64 QRKLDKLTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGR 128
            .||||||||||||||||:.::|:.|  .|..::|:|:||.|.|||.::|:|::|||||||||||:
Zfish   123 SRKLDKLTVLRMAVQHLKSLKGATS--SFAEANYKPAFLPDDELKHLVLRAADGFLFVVGCDRGK 185

  Fly   129 ILYVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVP 193
            |::||:|||..||.::.:|:|||.||.:|||||||||||||:.|..||||||||||.|.|:.::|
Zfish   186 IVFVSESVSKTLNYSRTELIGQSLFDYVHPKDIGKVKEQLSASELYPRERLIDAKTGLQVQAELP 250

  Fly   194 QSLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKS 258
            ....|||.|||||||||||....:   :|||.|..:.  :|.|::|:     :|..:.||||:::
Zfish   251 VGSARLCSGARRSFFCRMKYNKIT---VKEEKDFQAG--ASKKKESQ-----RYCTVHCTGYMRT 305

  Fly   259 WTPIKD--EDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKF 321
            | |.:.  .:.:|::|:::::.|||||:||:.|:    |:|.: :....::...|::|::.:|||
Zfish   306 W-PTRQLATEGEAEADKESSHFSCLVAMGRVHPH----TLPQA-NGEIKVKPTEFVTRYAMDGKF 364

  Fly   322 LFIDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQ 386
            .|:|||||.::|:||||:||||.|||||.:|:..|.|.|:.|::..||:.|..|:|:.|..|::.
Zfish   365 TFVDQRATTILGYLPQELLGTSCYEYFHLDDLPHLAERHRKVLRSKEKIETNCYKFKTKSGSFVN 429

  Fly   387 LQSEWRAFKNPWTSEIDYIIAKNSV 411
            |||:|.:|.||||.|::||::.|:|
Zfish   430 LQSQWFSFINPWTKEVEYIVSTNTV 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	36/58 (62%)
		PAS	111..212	CDD:279347	66/100 (66%)
		PAS	111..173	CDD:214512	40/61 (66%)
		PAS_11	311..411	CDD:291273	50/99 (51%)
		PAS	311..406	CDD:238075	48/94 (51%)
arntl2	NP_571653.2	HLH	91..143	CDD:306515	36/51 (71%)
		PAS	172..266	CDD:238075	61/93 (66%)
		PAS_3	353..456	CDD:330807	51/102 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4874
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1736
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm25200
orthoMCL	1	0.900	-	-		OOG6_106197
Panther	1	1.100	-	-	LDO	PTHR23042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2275
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970