DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyc and arntl1a

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_571652.1	Gene:	arntl1a / 58098	ZFINID:	ZDB-GENE-000509-1	Length:	626	Species:	Danio rerio

Alignment Length:	408	Identity:	216/408 - (52%)
Similarity:	297/408 - (72%)	Gaps:	18/408 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FCENMEEIEDENYD-EEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDK 69
            |.::|:..:|:... :|:..|.  :|.::.||:||||||||||::|:||:|::|.|.||.|||||
Zfish    53 FDDSMDTDKDKTLGRDEQQGRI--KNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDK 115

  Fly    70 LTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSD 134
            ||||||||||::.:|  |:.:|:..::|:|:||||.|||.:||:|::|||||||||||:||:||:
Zfish   116 LTVLRMAVQHMKTLR--GATNPYTEANYKPAFLSDDELKHLILRAADGFLFVVGCDRGKILFVSE 178

  Fly   135 SVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRL 199
            ||..:||.||.||:|||.||.||||||.||||||||.:..||||||||||.||||||:.....||
Zfish   179 SVYKILNYTQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRL 243

  Fly   200 CPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTPIK- 263
            |.|||||||||||....| .:::::...|:.|:....|||..|       |..|||||||.|.|
Zfish   244 CSGARRSFFCRMKCNRPS-VKMEDKDFPSTCSKKKADRKSFCT-------IHSTGYLKSWPPTKM 300

  Fly   264 DEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRA 328
            ..|:|.:.|.:..||||||||||:.|::    ||..::....::...::|||:.:|||:|:||||
Zfish   301 GLDEDNEPDNEGCNLSCLVAIGRLHPHI----VPQPMNGDIRVKPTEYVSRHAIDGKFVFVDQRA 361

  Fly   329 TLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRA 393
            |.::.:||||:||||||||||.:||..|.|.|:.|:|:.||::|..|:|:.||.|:|.|:|.|.:
Zfish   362 TAILAYLPQELLGTSFYEYFHQDDIGHLAECHRQVLQMREKISTNCYKFKIKDGSFITLRSRWFS 426

  Fly   394 FKNPWTSEIDYIIAKNSV 411
            |.||||.|::||::.|:|
Zfish   427 FMNPWTKEVEYIVSTNTV 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	35/52 (67%)
		PAS	111..212	CDD:279347	73/100 (73%)
		PAS	111..173	CDD:214512	45/61 (74%)
		PAS_11	311..411	CDD:291273	54/99 (55%)
		PAS	311..406	CDD:238075	52/94 (55%)
arntl1a	NP_571652.1	HLH	78..130	CDD:278439	35/51 (69%)
		PAS	150..257	CDD:279347	77/106 (73%)
		PAS	153..212	CDD:214512	41/58 (71%)
		PAS_11	343..446	CDD:291273	55/102 (54%)
		PAS	345..440	CDD:238075	53/94 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4874
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	425	1.000	Inparanoid score	I1736
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm25200
orthoMCL	1	0.900	-	-		OOG6_106197
Panther	1	1.100	-	-	O	PTHR23042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4528
SonicParanoid	1	1.000	-	-		X2275
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860