DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyc and ARNTL2

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001381453.1	Gene:	ARNTL2 / 56938	HGNCID:	18984	Length:	647	Species:	Homo sapiens

Alignment Length:	402	Identity:	198/402 - (49%)
Similarity:	270/402 - (67%)	Gaps:	25/402 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IEDENYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAV 77
            :||..:..:..|      .::.||:.|||||||||..|.|||:|||.|..|.|||||||||||||
Human   107 VEDGEHQVKMKA------FREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAV 165

  Fly    78 QHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNS 142
            ||||.::  |..:.:.||:||||||.|.||:.:||:.:|||||||||:||:||:||.|||.:||.
Human   166 QHLRSLK--GLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNY 228

  Fly   143 TQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSF 207
            .||.|.|||.||.|||||:.||||||||.:..|||:||||||.|.|.:::.....|:..|:||||
Human   229 DQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSRRSF 293

  Fly   208 FCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTP-IKDEDQDADS 271
            |||:|   :....:|||.....:|:....|        |:..|.|||||:||.| |...:::.:|
Human   294 FCRIK---SCKISVKEEHGCLPNSKKKEHR--------KFYTIHCTGYLRSWPPNIVGMEEERNS 347

  Fly   272 DEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLP 336
            .:..:|.:|||||||:.|.:    ||.: ....|::...||:|.:..|||:::|||||.::|:||
Human   348 KKDNSNFTCLVAIGRLQPYI----VPQN-SGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP 407

  Fly   337 QEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSE 401
            ||:||||.|||||.:|...|.:.||.|:|..||:.|..|:||.||.|::.|:|:|.:|.||||.|
Human   408 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKE 472

  Fly   402 IDYIIAKNSVFL 413
            ::||::.|::.|
Human   473 LEYIVSVNTLVL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	37/52 (71%)
		PAS	111..212	CDD:279347	63/100 (63%)
		PAS	111..173	CDD:214512	43/61 (70%)
		PAS_11	311..411	CDD:291273	52/99 (53%)
		PAS	311..406	CDD:238075	50/94 (53%)
ARNTL2	NP_001381453.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..73
		Interaction with PER2. /evidence=ECO:0000250\|UniProtKB:Q2VPD4	57..269		101/169 (60%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9WTL8	60..65
		bHLH-PAS_ARNTL2_PASD9	119..178	CDD:381475	38/60 (63%)
		Nuclear export signal 1. /evidence=ECO:0000250\|UniProtKB:Q9WTL8	188..198		4/9 (44%)
		PAS	203..298	CDD:238075	60/94 (64%)
		PAS_11	381..483	CDD:405306	52/101 (51%)
		Nuclear export signal 2. /evidence=ECO:0000250\|UniProtKB:Q9WTL8	403..411		5/7 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I5024
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1790
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm40507
orthoMCL	1	0.900	-	-		OOG6_106197
Panther	1	1.100	-	-	LDO	PTHR23042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2275
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830