DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cyc and sim

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_524340.2	Gene:	sim / 41612	FlyBaseID:	FBgn0004666	Length:	688	Species:	Drosophila melanogaster

Alignment Length:	398	Identity:	111/398 - (27%)
Similarity:	188/398 - (47%)	Gaps:	62/398 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHL--RGIRGSGSLHPFNG 94
            |:......:.||:|.||...||:.::|:..|:..:|||.:|:|:...:|  |.:...|....:..
  Fly    26 KEKSKNAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGS 90

  Fly    95 SDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLHPK 159
            |.......:.:||...:||..:||:|||..| |:|:|:|::.|..|..:|.:|.|.|.|:.:|..
  Fly    91 SPAMQRGATIKELGSHLLQTLDGFIFVVAPD-GKIMYISETASVHLGLSQVELTGNSIFEYIHNY 154

  Fly   160 DIGKVKEQLS---SLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGA------------RRSFFC 209
            |..::...||   .:.|.|.     |:|..|:.:  |..:..  |.|            .::||.
  Fly   155 DQDEMNAILSLHPHINQHPL-----AQTHTPIGS--PNGVQH--PSAYDHDRGSHTIEIEKTFFL 210

  Fly   210 RMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWT-PIKDEDQDADSDE 273
            |||...|                   ||.:.|||. .::||.|:||||:.. |.:.:.|.:
  Fly   211 RMKCVLA-------------------KRNAGLTTS-GFKVIHCSGYLKARIYPDRGDGQGS---- 251

  Fly   274 QTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLPQE 338
            ...||. |||:|.        ::|:|......:...:|:.|...:.|.:|.|.|.:.:.|:.||:
  Fly   252 LIQNLG-LVAVGH--------SLPSSAITEIKLHQNMFMFRAKLDMKLIFFDARVSQLTGYEPQD 307

  Fly   339 ILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSEID 403
            ::..:.|:|.|..||.|:..||:::: ...:|||:.|||..|...::.:||......|..:|...
  Fly   308 LIEKTLYQYIHAADIMAMRCSHQILL-YKGQVTTKYYRFLTKGGGWVWVQSYATLVHNSRSSREV 371

  Fly   404 YIIAKNSV 411
            :|::.|.|
  Fly   372 FIVSVNYV 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	17/53 (32%)
		PAS	111..212	CDD:279347	34/115 (30%)
		PAS	111..173	CDD:214512	23/64 (36%)
		PAS_11	311..411	CDD:291273	30/99 (30%)
		PAS	311..406	CDD:238075	28/94 (30%)
sim	NP_524340.2	HLH	26..78	CDD:238036	16/51 (31%)
		PAS	102..215	CDD:279347	38/122 (31%)
		PAS	102..163	CDD:214512	23/61 (38%)
		PAS	278..376	CDD:238075	29/98 (30%)
		PAS_3	291..377	CDD:285623	26/86 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910