DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cyc and tgo

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	NP_001262397.1	Gene:	tgo / 41084	FlyBaseID:	FBgn0264075	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	169/397 - (42%)
Similarity:	246/397 - (61%)	Gaps:	26/397 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ARTSDENR---KQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLRGIRG 85
            |...|:.|   ::||.|||:|||:||..||.|||.|:|.|.|:.||.||||:|||||.|::.:||
  Fly     4 ANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRG 68

  Fly    86 SGSLHPFNGSD--YRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLL 148
            :|:    ..||  |:||||:|||||.:||:|::||||||.||.||::||||||:.|||.||:|..
  Fly    69 TGN----TSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWY 129

  Fly   149 GQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARRSFFCRMKL 213
            |.|.::.:||.|..|::||||:.|.....|::|.|:. .||.:..||..||..||||.|.|||::
  Fly   130 GTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSG-TVKKEGHQSSMRLSMGARRGFICRMRV 193

  Fly   214 RTASNNQIKEESDTSSSSRSSTKRKS--RLTTGHKYRVIQCTGYLKSWTP---IKDEDQDADSDE 273
                 ..:..||..|.......:|.|  ....|..|.|:.||||:|:|.|   ..:...:.|.|:
  Fly   194 -----GNVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDD 253

  Fly   274 QTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLPQE 338
            .::: .|||||||:     ..|..|:.|...:.....||:||:.:|||.|:|||...::|:.|.|
  Fly   254 MSSH-CCLVAIGRL-----QVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTE 312

  Fly   339 ILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSEID 403
            :||...|::||.||.:.:.||...|::...::.:.:||.|.|::.|:.|:::..||.||:|.|::
  Fly   313 LLGKICYDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVE 377

  Fly   404 YIIAKNS 410
            ||:..||
  Fly   378 YIVCTNS 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	32/55 (58%)
		PAS	111..212	CDD:279347	52/100 (52%)
		PAS	111..173	CDD:214512	35/61 (57%)
		PAS_11	311..411	CDD:291273	40/100 (40%)
		PAS	311..406	CDD:238075	37/94 (39%)
tgo	NP_001262397.1	HLH	15..67	CDD:278439	31/51 (61%)
		PAS	87..192	CDD:279347	55/105 (52%)
		PAS	90..154	CDD:214512	35/63 (56%)
		PAS_11	283..384	CDD:291273	38/100 (38%)
		PAS	283..380	CDD:238075	37/96 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I6073
eggNOG	1	0.900	-	-		E1_KOG3561
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23042
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920