Protein Alignment cyc and BMAL1

DIOPT Version :10

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: XP_016873227.1
• Gene: BMAL1 / 406
• HGNCID: 701
• Length: 674
• Species: Homo sapiens
• Alignment Length: 415
• Identity: 216/415 - (52%)
• Similarity: 296/415 - (71%)
• Gaps: 23/415 - (5%)

  Fly     5 EFCENMEEIEDE-----NYDEEKSARTSDENRKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQ 64
            ::.|:|:..:|:     .|.|.:.   ..:|.::.||:||||||||||::|:||:|::|.|.||.
Human    88 DYQESMDTDKDDPHGRLEYTEHQG---RIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMS 149

  Fly    65 RKLDKLTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRI 129
            |||||||||||||||::.:|  |:.:|:..::|:|:||||.|||.:||:|::|||||||||||:|
Human   150 RKLDKLTVLRMAVQHMKTLR--GATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKI 212

  Fly   130 LYVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQ 194
            |:||:||..:||.:|.||:|||.||.||||||.||||||||.:..||||||||||.||||||:..
Human   213 LFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITP 277

  Fly   195 SLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSW 259
            ...|||.|||||||||||....| .:::::...|:.|:....|||..|       |..|||||||
Human   278 GPSRLCSGARRSFFCRMKCNRPS-VKVEDKDFPSTCSKKKADRKSFCT-------IHSTGYLKSW 334

  Fly   260 TPIK-DEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLF 323
            .|.| ..|:|.:.|.:..||||||||||:..:|    ||..::....::.:.::|||:.:|||:|
Human   335 PPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHV----VPQPVNGEIRVKSMEYVSRHAIDGKFVF 395

  Fly   324 IDQRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQ 388
            :|||||.::.:||||:||||.|||||.:||..|.|.|:.|:|..||:||..|:|:.||.|:|.|:
Human   396 VDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLR 460

  Fly   389 SEWRAFKNPWTSEIDYIIAKNSVFL 413
            |.|.:|.||||.|::||::.|:|.|
Human   461 SRWFSFMNPWTKEVEYIVSTNTVVL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	bHLH_SF	31..92	CDD:469605	37/60 (62%)
		PAS	111..173	CDD:214512	44/61 (72%)
		PAS_11	311..411	CDD:464214	54/99 (55%)
BMAL1	XP_016873227.1	bHLH-PAS_ARNTL_PASD3	110..173	CDD:381444	38/67 (57%)
		PAS	192..251	CDD:214512	40/58 (69%)
		PAS_11	382..484	CDD:464214	54/101 (53%)