Protein Alignment cyc and ARNT

DIOPT Version :9

• Sequence 1: NP_524168.2
• Gene: cyc / 40162
• FlyBaseID: FBgn0023094
• Length: 413
• Species: Drosophila melanogaster
• Sequence 2: NP_001659.1
• Gene: ARNT / 405
• HGNCID: 700
• Length: 789
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 168/410 - (40%)
• Similarity: 255/410 - (62%)
• Gaps: 35/410 - (8%)

  Fly    19 DEEKSARTSDEN--------RKQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRM 75
            |:|:.||:.||.        .::||||||:|||:||..||.|||.|:|.|.|:.||.||||:|||
Human    70 DKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRM 134

  Fly    76 AVQHLRGIRGSGSLHPFNGSDYRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVL 140
            ||.|::.:||:|:... :|| |:||||:|||||.:||:|::||||:|.|:.||::||||||:.||
Human   135 AVSHMKSLRGTGNTST-DGS-YKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVL 197

  Fly   141 NSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQSLCRLCPGARR 205
            |..|::..|.:.:|.:||.|:.|::||||:.|.....|::|.||. .||.:..||..|:|.|:||
Human   198 NQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTG-TVKKEGQQSSMRMCMGSRR 261

  Fly   206 SFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGH------KYRVIQCTGYLKSWTP--- 261
            ||.|||:..::|.:.:      |.:..|..:.:.|...|.      .:.|:.||||:|:|.|
Human   262 SFICRMRCGSSSVDPV------SVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGV 320

  Fly   262 -IKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFID 325
             :.|:|.:|....:    .|||||||:  .|.:|  |...|.....:...|||||:.||.|.|:|
Human   321 SLPDDDPEAGQGSK----FCLVAIGRL--QVTSS--PNCTDMSNVCQPTEFISRHNIEGIFTFVD 377

  Fly   326 QRATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSE 390
            .|....:|:.|||:||.:..|:.|.||...|.:|.:.|:::..:|.:.::|||.|:..::.:::.
Human   378 HRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTS 442

  Fly   391 WRAFKNPWTSEIDYIIAKNS 410
            ...|:||::.||:|||..|:
Human   443 SFTFQNPYSDEIEYIICTNT 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	32/52 (62%)
		PAS	111..212	CDD:279347	49/100 (49%)
		PAS	111..173	CDD:214512	31/61 (51%)
		PAS_11	311..411	CDD:291273	38/100 (38%)
		PAS	311..406	CDD:238075	35/94 (37%)
ARNT	NP_001659.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..97		9/26 (35%)
		DNA-binding. /evidence=ECO:0000269|PubMed:28396409	88..128		22/39 (56%)
		HLH	91..143	CDD:278439	32/51 (63%)
		Required for heterodimer formation with EPAS1. /evidence=ECO:0000250|UniProtKB:P53762	112..264		79/154 (51%)
		Required for heterodimer formation with HIF1A. /evidence=ECO:0000250|UniProtKB:P53762	112..168		33/57 (58%)
		PAS	163..269	CDD:279347	53/106 (50%)
		PAS	166..230	CDD:214512	31/63 (49%)
		Mediates the transcription activity and dimerization of the AHR:ARNT complex. /evidence=ECO:0000250|UniProtKB:P53762	167..171		2/3 (67%)
		PAS_11	362..462	CDD:291273	37/99 (37%)
		PAS	362..458	CDD:238075	35/95 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	465..492
		Med3	<523..>734	CDD:288447
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	672..789

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3561
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820