DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cyc and Arntl2

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_038963872.1	Gene:	Arntl2 / 362464	RGDID:	620230	Length:	625	Species:	Rattus norvegicus

Alignment Length:	399	Identity:	180/399 - (45%)
Similarity:	251/399 - (62%)	Gaps:	43/399 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KQNHSEIEKRRRDKMNTYINELSSMIPMCFAMQRKLDKLTVLRMAVQHLRGIRGSGSLHPFNGSD 96
            ::.||:.|||||||||..|.:||||||.......|||||::||.|||:||..||....  :.|.:
  Rat    88 REAHSQTEKRRRDKMNHLIWKLSSMIPPHIPTAHKLDKLSILRRAVQYLRSQRGMTEF--YLGEN 150

  Fly    97 YRPSFLSDQELKMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLHPKDI 161
            .:|||:.|:||..:||:|:||||.||||:.||||:||.|||..|:..||.|:||:.||.|.|||:
  Rat   151 AKPSFIQDKELSHLILKAAEGFLLVVGCEGGRILFVSKSVSKTLHYDQASLMGQNLFDFLQPKDV 215

  Fly   162 GKVKEQLS---SLEQCPRERLIDAKTMLPVKTDVPQSLC-------------RLCPGARRSFFCR 210
            .|||||||   ||    ||:.|..|:...:     |||.             |:..|:|||||.|
  Rat   216 AKVKEQLSCDVSL----REKPIGTKSEFFL-----QSLASPQVHSHSHIGRSRVHSGSRRSFFFR 271

  Fly   211 MKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQCTGYLKSWTP-IKDEDQDADSDEQ 274
            ||  ::....:|||...||.|:...:|        |:..|.|||||:||.| :...:::..|.:.
  Rat   272 MK--SSCTVPVKEEQRCSSCSKKKDQR--------KFHTIHCTGYLRSWPPNVVGTEKEMGSGKD 326

  Fly   275 TTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLPQEI 339
            :..|:||||:||:.|    .|||.. :...|:|...||:|.:..|||:::|||||.::|:||||:
  Rat   327 SGPLTCLVAMGRLQP----YTVPPK-NGKINVRPAEFITRFAMNGKFVYVDQRATAILGYLPQEL 386

  Fly   340 LGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQLQSEWRAFKNPWTSEIDY 404
            ||||.|||||.:|.:.|.:.||.|:|..||:.|..|:||.||.|::.|:|:|.:|.||||.:::|
  Rat   387 LGTSCYEYFHQDDHSNLSDKHKAVLQSKEKILTDSYKFRVKDGSFVTLKSKWFSFTNPWTKKLEY 451

  Fly   405 IIAKNSVFL 413
            |::.|::.|
  Rat   452 IVSVNTLVL 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	30/51 (59%)
		PAS	111..212	CDD:279347	56/116 (48%)
		PAS	111..173	CDD:214512	41/64 (64%)
		PAS_11	311..411	CDD:291273	51/99 (52%)
		PAS	311..406	CDD:238075	49/94 (52%)
Arntl2	XP_038963872.1	bHLH_SF	87..146	CDD:412148	32/59 (54%)
		PAS	171..268	CDD:238075	48/105 (46%)
		PAS_11	357..464	CDD:405306	52/104 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4878
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168098at33208
OrthoFinder	1	1.000	-	-		FOG0000695
OrthoInspector	1	1.000	-	-		otm44650
orthoMCL	1	0.900	-	-		OOG6_106197
Panther	1	1.100	-	-	LDO	PTHR23042
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2275
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.920