DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cyc and Ncoa1

DIOPT Version :9

Sequence 1:	NP_524168.2	Gene:	cyc / 40162	FlyBaseID:	FBgn0023094	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_017449617.1	Gene:	Ncoa1 / 313929	RGDID:	1309046	Length:	1443	Species:	Rattus norvegicus

Alignment Length:	409	Identity:	91/409 - (22%)
Similarity:	159/409 - (38%)	Gaps:	108/409 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DEEKSARTSDENRKQNH------SEIEKRRRDKMNTYINELSSMIPMCF----AMQRKLDKLTVL 73
            |........|.::::..      |..|||||::.|.|:.||:.::....    ::..|.||..:|
  Rat     6 DSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKIL 70

  Fly    74 RMAVQHLRGIRGSGSLHPFNGSDYRPSFLSD--------QELKMIILQASEGFLFVVGCDRGRIL 130
            :..|..::.::...........|.:.|.:|.        :.|..::|:|.:||.|||.|: |||:
  Rat    71 KKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCE-GRIV 134

  Fly   131 YVSDSVSSVLNSTQADLLGQSWFDVLHPKDIGKVKEQLSSLEQCPRERLIDAKTMLPVKTDVPQS 195
            :||::|:|.|...|.:|:..|.:.:||..|..:.                       ||..:|:|
  Rat   135 FVSENVTSYLGYNQEELMNTSVYSILHVGDHAEF-----------------------VKNLLPKS 176

  Fly   196 LCRLCP----GARR---SFFCRMKLRTASNNQIKEESDTSSSSRSSTKRKSRLTTGHKYRVIQC- 252
            |....|    ..||   :|.|||.:..      .:|..|.:....           .:|.|:||
  Rat   177 LVNGVPWPQEATRRNSHTFNCRMLIHP------PDEPGTENQEAC-----------QRYEVMQCF 224

  Fly   253 -TGYLKSWTPIKDEDQDADSDEQTTNLSCLVAIGRIPPNVRNSTVPASLDNHPNIRHV-LFISRH 315
             ....||   |:::.:|..        |||:.|.|            .|...|.|..| .|:::.
  Rat   225 TVSQPKS---IQEDGEDFQ--------SCLICIAR------------RLPRPPAITGVESFMTKQ 266

  Fly   316 SGEGKFLFIDQ---RATLVIGFLPQEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQ---- 373
            ...||.:.||.   ||....|:  ::::....|.:|..:.     .......|:.::|.|:
  Rat   267 DTTGKIISIDTSSLRAAGRTGW--EDLVRKCIYAFFQPQG-----REPSYARQLFQEVMTRGTAS 324

  Fly   374 --VYRFRCKDNSYIQLQSE 390
              .|||...|.:.:...::
  Rat   325 SPSYRFILNDGTMLSAHTK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cyc	NP_524168.2	HLH	31..84	CDD:278439	15/62 (24%)
		PAS	111..212	CDD:279347	33/107 (31%)
		PAS	111..173	CDD:214512	22/61 (36%)
		PAS_11	311..411	CDD:291273	17/89 (19%)
		PAS	311..406	CDD:238075	17/89 (19%)
Ncoa1	XP_017449617.1	bHLH-PAS_NCoA1_SRC1	27..87	CDD:381518	15/59 (25%)
		PAS	120..213	CDD:238075	34/122 (28%)
		PAS_11	260..370	CDD:405306	17/91 (19%)
		NCOA_u2	469..591	CDD:406952
		SRC-1	633..709	CDD:400955
		DUF4927	744..821	CDD:406644
		Nuc_rec_co-act	927..972	CDD:400942
		Med15	995..>1362	CDD:312941
		DUF1518	1152..1208	CDD:400033
		DUF1518	1215..1270	CDD:400033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910